Document Detail

High dose intravenous streptokinase for acute myocardial infarction: preliminary results of a multicenter trial.
MedLine Citation:
PMID:  4045046     Owner:  NLM     Status:  MEDLINE    
To assess the efficacy of intravenous streptokinase in patients with acute myocardial infarction, 40 patients (30 men and 10 women, mean age 54 years) with acute myocardial infarction were given 1.5 million U of streptokinase intravenously in 1 hour, and coronary arteriography was performed repeatedly to assess reperfusion. Streptokinase treatment was begun 270 +/- 86 (mean +/- SD) minutes after the onset of chest pain. Of the 40 patients, 34 had total or near total coronary occlusion before streptokinase administration. In 14 (41%) of these 34 patients, some reperfusion occurred during the 90 minutes after the administration of streptokinase, but in only 11 of the 14 was reperfusion present at 90 minutes. After streptokinase administration, all patients received heparin for 8 to 10 days; they were subsequently administered aspirin and dipyridamole. Clinical evidence of reocclusion during the first 24 hours of heparin therapy occurred in one patient. Thus, when given to patients with acute myocardial infarction and total coronary occlusion an average of 4 1/2 hours after the onset of chest pain, high dose intravenous streptokinase achieves reperfusion in only about 40% and results in sustained reperfusion in only about 30%.
L D Hillis; J Borer; E Braunwald; J H Chesebro; L S Cohen; J Dalen; H T Dodge; C K Francis; G Knatterud; P Ludbrook
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the American College of Cardiology     Volume:  6     ISSN:  0735-1097     ISO Abbreviation:  J. Am. Coll. Cardiol.     Publication Date:  1985 Nov 
Date Detail:
Created Date:  1985-11-21     Completed Date:  1985-11-21     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8301365     Medline TA:  J Am Coll Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  957-62     Citation Subset:  AIM; IM    
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MeSH Terms
Aspirin / therapeutic use
Coronary Angiography
Dipyridamole / therapeutic use
Drug Evaluation
Fibrin Fibrinogen Degradation Products / analysis
Fibrinogen / analysis
Heparin / therapeutic use
Infusions, Parenteral
Middle Aged
Myocardial Infarction / blood,  drug therapy*,  mortality
Plasminogen / analysis
Streptokinase / administration & dosage*,  therapeutic use
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 50-78-2/Aspirin; 58-32-2/Dipyridamole; 9001-32-5/Fibrinogen; 9001-91-6/Plasminogen; 9005-49-6/Heparin; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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