Document Detail

High-dose intravenous immunoglobulin in myasthenia gravis.
MedLine Citation:
PMID:  8314677     Owner:  NLM     Status:  MEDLINE    
The effects of high-dose intravenous immunoglobulin (i.v.Ig) in 12 MG patients were studied. All patients had severe symptoms. In two cases anti-acetylcholine receptor antibodies (anti-AChR abs) were not detectable. I.v.Ig was administered to 9 patients already on long-term immunosuppressive therapy and to 3 patients at the beginning of azathioprine treatment. 10 patients (83%) improved; the duration of improvement was longer in immunosuppressed patients. Anti-AChR abs generally decreased after infusion but we did not find a constant correlation between reduction in ab titers and clinical improvement. Side effects included one case of severe hemolysis. In our experience i.v.Ig therapy is effective in MG. The chief indication for its use appears to be the treatment of deterioration of the disease in patients already on immunosuppressive therapy.
A Evoli; M T Palmisani; E Bartoccioni; L Padua; P Tonali
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Italian journal of neurological sciences     Volume:  14     ISSN:  0392-0461     ISO Abbreviation:  Ital J Neurol Sci     Publication Date:  1993 Apr 
Date Detail:
Created Date:  1993-07-29     Completed Date:  1993-07-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8006502     Medline TA:  Ital J Neurol Sci     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  233-7     Citation Subset:  IM    
Istituto di Neurologia, Università Cattolica, Roma.
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MeSH Terms
Antibodies / analysis
Dose-Response Relationship, Drug
Immunization, Passive*
Immunoglobulins / administration & dosage*
Injections, Intravenous
Middle Aged
Myasthenia Gravis / immunology,  therapy*
Receptors, Cholinergic / immunology
Reg. No./Substance:
0/Antibodies; 0/Immunoglobulins; 0/Receptors, Cholinergic

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