Document Detail

High-dose intravenous corticosteroids in the treatment of multiple sclerosis.
MedLine Citation:
PMID:  3626160     Owner:  NLM     Status:  MEDLINE    
The effectiveness of high-dose intravenous corticosteroid therapy for acute bouts of multiple sclerosis (MS) was evaluated in comparison with the conventional oral prednisolone therapy. Group I comprised 11 cases of MS treated with oral prednisolone, 30-60 mg daily, and group II comprised 16 cases treated with intravenous corticosteroids; 11 cases given 1000 mg of methylprednisolone for the initial 3 days followed by 100 mg of prednisolone, while the remaining 5 were given 100 mg of prednisolone alone. The initial dosage was maintained for 1 or 2 weeks in each group, tailing off with a period of several weeks of oral prednisolone. The clinical status was evaluated using Kurtzke's expanded disability status scale (EDSS) and functional system scale before and 1, 2 and 4 weeks after the initiation of therapy. EDSS score significantly declined from week 0 (before) to weeks 1, 2 and 4 in group II, respectively, whereas no significant decline of EDSS score was observed in group I. The frequency of improvement (0.5 of an increment in EDSS score) in group II was significantly higher than that in group I at weeks 1, 2 and 4. It was thus suggested that high-dose intravenous corticosteroid therapy might be more useful in acute bouts of MS, especially for obtaining an early improvement, than conventional oral prednisolone therapy.
R Ohno; K Hamaguchi; K Sowa; H Tanaka; Y Watanabe
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Japanese journal of medicine     Volume:  26     ISSN:  0021-5120     ISO Abbreviation:  Jpn. J. Med.     Publication Date:  1987 May 
Date Detail:
Created Date:  1987-10-20     Completed Date:  1987-10-20     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0247713     Medline TA:  Jpn J Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  212-6     Citation Subset:  IM    
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MeSH Terms
Administration, Oral
Adrenal Cortex Hormones / administration & dosage,  therapeutic use*
Disability Evaluation
Injections, Intravenous
Methylprednisolone / administration & dosage,  therapeutic use
Middle Aged
Multiple Sclerosis / drug therapy*,  physiopathology
Prednisolone / administration & dosage,  therapeutic use
Reg. No./Substance:
0/Adrenal Cortex Hormones; 50-24-8/Prednisolone; 83-43-2/Methylprednisolone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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