Document Detail

High-dose intraperitoneal aprotinin treatment of acute severe pancreatitis: a double-blind randomized multi-center trial.
MedLine Citation:
PMID:  7524945     Owner:  NLM     Status:  MEDLINE    
A multi-center double-blind trial was performed on 48 patients with severe acute pancreatitis. All patients were treated with intraperitoneal lavage. One group (n = 22) was also treated with high doses of the protease inhibitor, aprotinin (Trasylol; Bayer AG, Leverkusen, Germany) administered intraperitoneally. Eight patients died, giving a total mortality of 16.6%. No difference was observed between the two groups. Altogether, 12 patients were operated on, corresponding to 25%. In the group not treated with aprotinin, 6 patients were operated on because of pancreatic necrosis, compared with none in the treated group. The difference was statistically significant. There were no significant differences between the two groups with regard to organ failure or other complications. It was concluded that aprotinin counteracts the development of pancreatic necrosis when given intraperitoneally in high doses to patients with severe acute pancreatitis, thus reducing the need for surgical intervention in these patients.
R Berling; S Genell; K Ohlsson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study; Randomized Controlled Trial; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of gastroenterology     Volume:  29     ISSN:  0944-1174     ISO Abbreviation:  J. Gastroenterol.     Publication Date:  1994 Aug 
Date Detail:
Created Date:  1994-11-30     Completed Date:  1994-11-30     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9430794     Medline TA:  J Gastroenterol     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  479-85     Citation Subset:  IM    
Department of Anaesthesiology, Malmö General Hospital, University of Lund, Sweden.
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MeSH Terms
Acute Disease
Aged, 80 and over
Aprotinin / administration & dosage*,  therapeutic use
Chi-Square Distribution
Double-Blind Method
Middle Aged
Pancreas / pathology
Pancreatitis / drug therapy*,  pathology
Peritoneal Lavage
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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