| High-dose fentanyl for rapid induction of anaesthesia in patients with coronary artery disease. | |
| | |
MedLine Citation:
|
PMID: 2862978 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Nine premedicated patients, chronically maintained on beta-adrenergic blocking agents and demonstrating good ventricular function without significant valvular or left main coronary artery disease, were investigated to determine their haemodynamic responses to rapid induction of anaesthesia and tracheal intubation during elective coronary artery bypass surgery. Fentanyl 50 micrograms X kg-1 and pancuronium 0.15 mg X kg-1 were administered intravenously over 20 seconds followed by tracheal intubation 90 seconds thereafter. The rapid sequence of anaesthetic induction and tracheal intubation was well tolerated by all patients. Though statistically significant changes were detected in heart rate, pulmonary capillary wedge pressure and systemic vascular resistance, these changes were small and not considered clinically significant and no signs of ischaemia were detected on the ECG. The present study demonstrates that high-dose fentanyl is capable of inducing anaesthesia rapidly and protecting against the haemodynamic changes associated with tracheal intubation. |
| | |
Authors:
|
J M Murkin; C C Moldenhauer; C C Hug |
Related Documents
:
|
18731818 - Mechanism of syncope and action of drugs in complete heart block. 1269128 - The conducting tissues in primitive ventricular hearts without an outlet chamber. 19520378 - Left bundle-branch block with right axis deviation--a unique aberrancy during supravent... 9309758 - Deglutition syncope associated with carotid sinus hypersensitivity. 12431318 - Cardiac effects of chronic oral beta-blockade: lack of agreement between heart rate and... 8694598 - Efficacy and cost-effectiveness of preoperative iabp in patients with ejection fraction... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Canadian Anaesthetists' Society journal Volume: 32 ISSN: 0008-2856 ISO Abbreviation: Can Anaesth Soc J Publication Date: 1985 Jul |
Date Detail:
|
Created Date: 1985-10-08 Completed Date: 1985-10-08 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 0371163 Medline TA: Can Anaesth Soc J Country: CANADA |
Other Details:
|
Languages: eng Pagination: 320-5 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adrenergic beta-Antagonists
/
therapeutic use Adult Aged Anesthesia* Blood Pressure / drug effects Coronary Artery Bypass* Female Fentanyl / pharmacology* Heart Rate / drug effects Humans Male Middle Aged Pancuronium / pharmacology Time Factors |
| Chemical | |
Reg. No./Substance:
|
0/Adrenergic beta-Antagonists; 0/Pancuronium; 437-38-7/Fentanyl |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Influence of 3 beta-blockers on the diameter of glomeruli isolated from the renal cortex of rats
Next Document: Alfentanil as an adjunct to thiopentone and nitrous oxide in short surgical procedures.