Document Detail


High dose dipyridamole as a pharmacological stress test during cardiac catheterisation in patients with coronary artery disease.
MedLine Citation:
PMID:  8800986     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To validate dipyridamole as a pharmacological stress test during cardiac catheterisation, allowing both functional and morphological estimation of stenosis severity. METHODS: The study encompassed 74 patients: 62 patients with significant coronary artery disease (age 61 (SD 8) years; seven women, 55 men) and 12 controls. Regional wall motion, left ventricular ejection fraction and end diastolic pressure were analysed in the resting state and after high dose intravenous dipyridamole. Patients were subdivided into four groups: group I (n = 32, 43%) had stopped all anti-ischaemic treatment for > 24 h, group II (n = 14, 19%) was under treatment, group III (n = 16, 22%) had significant coronary artery disease only in regions with regional wall motion abnormalities at rest, and group IV consisted of 12 control patients (16%) with no significant coronary artery disease (age 62 (8) years, three women, nine men). RESULTS: The sensitivity of dipyridamole testing in patients with coronary artery disease was poor. The best sensitivity was obtained with regional wall motion analysis (26/62 = 42%) and with global left ventricular ejection fraction (25/62 = 40%). Specificity was 100% for regional wall motion and 100% for ejection fraction. Calculated positive and negative predictive values for regional wall motion were 100% and 63%, respectively. CONCLUSIONS: Although safe, handy, and inexpensive, dipyridamole is not an adequate pharmacological stress test during cardiac catheterisation because of its low sensitivity.
Authors:
P Wagdi; U Kaufmann; M Fluri; B Meier
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Heart (British Cardiac Society)     Volume:  75     ISSN:  1355-6037     ISO Abbreviation:  Heart     Publication Date:  1996 Mar 
Date Detail:
Created Date:  1996-09-30     Completed Date:  1996-09-30     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  9602087     Medline TA:  Heart     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  247-51     Citation Subset:  AIM; IM    
Affiliation:
Department of Cardiology, University Hospital, Bern, Switzerland.
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MeSH Terms
Descriptor/Qualifier:
Coronary Disease / diagnosis*,  physiopathology
Dipyridamole / diagnostic use*
Drug Administration Schedule
Echocardiography*
Female
Heart Catheterization*
Humans
Male
Middle Aged
Predictive Value of Tests
Sensitivity and Specificity
Vasodilator Agents / diagnostic use*
Ventricular Function, Left
Chemical
Reg. No./Substance:
0/Vasodilator Agents; 58-32-2/Dipyridamole
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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