Document Detail

High-dose dexamethasone in quinine-treated patients with cerebral malaria: a double-blind, placebo-controlled trial.
MedLine Citation:
PMID:  3042874     Owner:  NLM     Status:  MEDLINE    
We compared placebo and dexamethasone (initial dose, 3 mg/kg; total, 11.4 mg/kg per 48 h) in a double-blind trial involving 10 stuporous and 28 comatose patients with cerebral malaria. Patients were 18 mo to 42 y of age (geometric mean, 10.2 y), and the 19 patients in each group were comparable on admission. All patients received intravenous quinine therapy. Four patients (21%) in each group died. There were no significant differences between the placebo- and dexamethasone-treated groups in time until patients became afebrile (median, 51 vs. 19 h), the level of consciousness became normal (mean, 80 vs. 83 h), or parasitemia was cleared (mean, 2.1 vs. 3.4 d) or in the incidence of complications. Coma or hyperparasitemia (greater than or equal to 5% of erythrocytes parasitized) at the time of admission and hypoglycemia at any time during hospitalization were significantly correlated with a fatal outcome, which was not improved by using dexamethasone. We conclude that high-dose dexamethasone is not indicated for treating cerebral malaria.
S L Hoffman; D Rustama; N H Punjabi; B Surampaet; B Sanjaya; A J Dimpudus; K T McKee; F P Paleologo; J R Campbell; H Marwoto
Related Documents :
8537694 - Effectiveness of levosulpiride versus metoclopramide for nausea and vomiting in advance...
23706134 - Subthalamic nucleus deep brain stimulation for parkinson's disease: 8 years of follow-up.
10405234 - Sulpiride versus metoclopramide in nononcologic patients with vomiting or nausea.
23614094 - Efficacy of the maze procedure for atrial fibrillation associated with atrial septal de...
17890274 - Conservative treatments for tennis elbow do subgroups of patients respond differently?
23456014 - Phrenic nerve injury after paediatric heart surgery: is aggressive plication of the dia...
Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  The Journal of infectious diseases     Volume:  158     ISSN:  0022-1899     ISO Abbreviation:  J. Infect. Dis.     Publication Date:  1988 Aug 
Date Detail:
Created Date:  1988-09-15     Completed Date:  1988-09-15     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0413675     Medline TA:  J Infect Dis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  325-31     Citation Subset:  AIM; IM    
U. S. Naval Medical Research Unit Number 2, Jakarta Detachment, Indonesia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Brain Diseases / drug therapy*,  mortality,  parasitology
Child, Preschool
Clinical Trials as Topic
Dexamethasone / adverse effects,  therapeutic use*
Double-Blind Method
Malaria / drug therapy*,  mortality,  parasitology
Plasmodium falciparum
Quinine / therapeutic use*
Random Allocation
Reg. No./Substance:
130-95-0/Quinine; 50-02-2/Dexamethasone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Immunization with rough mutants of Salmonella minnesota: initial studies in human subjects.
Next Document:  Comparative pharmacokinetics and pharmacodynamics of amikacin and ceftazidime in tricuspid and aorti...