| High-dose clinical urography with the low-osmolality contrast agent Hexabrix: comparison with a conventional contrast agent. | |
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MedLine Citation:
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PMID: 3538156 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A double-blind clinical trial was performed in 60 patients to compare Hexabrix (ioxaglate meglumine and ioxaglate sodium) and Renografin-60 (diatrizoate meglumine and diatrizoate sodium). Use of Hexabrix produced higher urinary iodine concentrations, lower urine volumes at 30 minutes, and excretory urograms significantly better in diagnostic quality, as rated by four independent observers. There was no difference in nephrogram quality between contrast agents. Patients receiving Hexabrix had less of an increase in heart rate and demonstrated a slight rise in mean arterial blood pressure, rather than the biphasic rise then fall seen with Renografin-60. There was no significant change for up to 96 hours after urography in results of hematology, clinical chemistry, or urinalysis, except for an increase of 0.005 in urine specific gravity with Renografin-60. Patients reported significantly less body heat, heat in the injection arm, and overall discomfort with Hexabrix. There was a similar amount of nausea and vomiting in the two groups. Hexabrix also caused histaminic-type reactions in three patients. |
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Authors:
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R F Spataro; R W Katzberg; H W Fischer; M J McMannis |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Controlled Clinical Trial; Journal Article |
Journal Detail:
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Title: Radiology Volume: 162 ISSN: 0033-8419 ISO Abbreviation: Radiology Publication Date: 1987 Jan |
Date Detail:
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Created Date: 1987-01-21 Completed Date: 1987-01-21 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0401260 Medline TA: Radiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 9-14 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aged, 80 and over Blood Pressure / drug effects Clinical Trials as Topic Diatrizoate* / administration & dosage, adverse effects, pharmacology Diatrizoate Meglumine* / administration & dosage, adverse effects, pharmacology Drug Combinations / administration & dosage, adverse effects, pharmacology Female Humans Iodine / urine Ioxaglic Acid* / administration & dosage, adverse effects, pharmacology Male Middle Aged Osmolar Concentration Urography* |
| Chemical | |
Reg. No./Substance:
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0/Drug Combinations; 117-96-4/Diatrizoate; 131-49-7/Diatrizoate Meglumine; 59017-64-0/Ioxaglic Acid; 7553-56-2/Iodine; 8064-12-8/urovision |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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