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High-dose calcium reduces early-onset hyperkalemia in extremely preterm neonates.
MedLine Citation:
PMID:  22924991     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
BACKGROUND: Early-onset hyperkalemia often occurs in extremely preterm infants during a few days after birth. While there are several treatments for hyperkalemia, calcium infusion to reduce plasma potassium concentrations remains controversial. The purpose of this study is to investigate whether a high dosage of calcium reduces early-onset hyperkalemia. METHODS: Extremely low birth weight neonates born at 22 to 25 weeks' gestation were enrolled. We analyzed data using multivariate regression analysis and performed a retrospective cohort study with patients divided into 2 groups according to the dosage of calcium in their initial infusion. RESULTS: One hundred three patients were eligible. Early-onset hyperkalemia was observed in 27 patients. The dosage of calcium gluconate during 24 hours after birth was the only independent factor affecting early-onset hyperkalemia. The maximum plasma potassium concentration during 72 hours after birth was negatively correlated with the dosage of calcium. High-dose calcium reduced occurrences of hyperkalemia and hypoglycemia caused by insulin infusion given for treatment of hyperkalemia, without increasing the risk of any other complications. CONCLUSIONS: Infusion of calcium gluconate may reduce early-onset hyperkalemia in a dose-dependent manner.
Authors:
Masahiro Enomoto; Hirotaka Minami; Tsutomu Takano; Yoshinori Katayama; Yong Kye Lee
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-8-28
Journal Detail:
Title:  Pediatrics international : official journal of the Japan Pediatric Society     Volume:  -     ISSN:  1442-200X     ISO Abbreviation:  Pediatr Int     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-8-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100886002     Medline TA:  Pediatr Int     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 The Author. Pediatrics International © 2012 Japan Pediatric Society.
Affiliation:
Department of Pediatrics and Neonatology, Takatsuki General Hospital, 1-3-13, Kosobe-cho, Takatsuki, Osaka, 650-0017, Japan; Department of Pediatrics, The Hospital for Sick Children, University of Toronto, 555 University Avenue, Toronto, Ontario, M5G 1X8, Canada.
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