Document Detail

High-dose caffeine suppresses postoperative apnea in former preterm infants.
MedLine Citation:
PMID:  2672899     Owner:  NLM     Status:  MEDLINE    
Thirty-two former preterm infants (less than or equal to 44 weeks postconceptual age) undergoing inguinal hernia repair were prospectively studied. General inhalational anesthesia with neuromuscular blockade was used. No barbiturates or opioids were given. Infants were randomly divided into two groups. Group 1 received iv caffeine 10 mg/kg immediately after induction of anesthesia. Group 2 received iv saline. Respiratory pattern, heart rate, and SpO2 were monitored using an impedance pneumograph and a pulse oximeter, respectively, for at least 12 h postoperatively. Tracings were analyzed for evidence of apnea, periodic breathing, and/or bradycardia by a pulmonologist unaware of the drug given. None of the patients who received caffeine developed postoperative bradycardia, prolonged apnea, or periodic breathing, and none had postoperative SpO2 less than 90%. In the control group 13 (81%) developed prolonged apnea 4-6 h postoperatively. Fifty percent of the patients had SpO2 less than 90% at the time. This study shows that iv caffeine 10 mg/kg is effective in the control of apnea in otherwise healthy expremature infants between 37 and 44 weeks of postconceptual age. It is still recommended, however, that all infants at risk be monitored for at least 12 h for apnea and bradycardia following general anesthesia.
L G Welborn; R S Hannallah; R Fink; U E Ruttimann; J M Hicks
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Anesthesiology     Volume:  71     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1989 Sep 
Date Detail:
Created Date:  1989-10-03     Completed Date:  1989-10-03     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  347-9     Citation Subset:  AIM; IM    
Department of Anesthesiology, Children's National Medical Center, Washington, D.C. 20010.
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MeSH Terms
Anesthesia, General
Apnea / epidemiology,  prevention & control*
Bradycardia / epidemiology,  prevention & control
Caffeine / administration & dosage*
Clinical Trials as Topic
Double-Blind Method
Hernia, Inguinal / surgery
Infant, Newborn
Infant, Premature*
Monitoring, Physiologic
Postoperative Complications / epidemiology,  prevention & control*
Prospective Studies
Random Allocation
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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