Document Detail


High-dose, brief-duration intravenous infusion of streptokinase in acute myocardial infarction: description of effects in the circulation.
MedLine Citation:
PMID:  3717017     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The effects in the circulating blood of a 1-hour intravenous infusion of 1.5 X 10(6) units of streptokinase (SK) were measured during the subsequent 24-hour period in 7 patients with acute myocardial infarction. At the end of the infusion, the activator activity, expressed in SK units, averaged 65 U/ml, all of the plasminogen had disappeared, only a small amount of free plasmin was still present and functionally active alpha 2 antiplasmin had been reduced to 21% of the preinfusion level. All of the native fibrinogen had been degraded and the thrombin-coagulable protein was composed entirely of fragment X species, but the circulating plasma also contained significant amounts of the more extensively degraded fragments Y, D and E. The biologic half-life of the SK-induced activator activity was 23 minutes and that of the fibrinogen degradation products was 6.3 hours. The lytic effects persisted for 4 hours before any signs of recovery from the hemostatic defect were evident; considerable recovery was present at 25 hours.
Authors:
R L Mentzer; A Z Budzynski; S Sherry
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  The American journal of cardiology     Volume:  57     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  1986 Jun 
Date Detail:
Created Date:  1986-06-27     Completed Date:  1986-06-27     Revised Date:  2009-11-19    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1220-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Fibrin Fibrinogen Degradation Products / blood
Humans
Infusions, Parenteral
Myocardial Infarction / drug therapy*
Plasminogen / blood
Streptokinase / administration & dosage*,  therapeutic use
alpha-2-Antiplasmin / blood
Grant Support
ID/Acronym/Agency:
HL14217/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Fibrin Fibrinogen Degradation Products; 0/alpha-2-Antiplasmin; 9001-91-6/Plasminogen; EC 3.4.-/Streptokinase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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