Document Detail

High-dose barbiturate therapy in humans: a clinical review of 60 patients.
MedLine Citation:
PMID:  534417     Owner:  NLM     Status:  MEDLINE    
Over the past three years, high-dose barbiturate therapy has been used in the treatment of 60 patients with head injury (N = 45), encephalitis (N = 8), acute focal cerebral ischemia (stroke, N = 4), and global anoxia secondary to drowning (N = 3). High-dose barbiturates appear to be useful adjuncts in the control of intracranial hypertension refractory to other methods of therapy. Administration of barbiturates to patients with this problem will often reduce the requirement for osmotic agents, thereby facilitating medical management by avoiding hyperosmolality and fluid and electrolyte depletion. In a carefully controlled intensive care setting the risk of barbiturate therapy is low, though the costs and demands on personnel are great. Survival appeared to be improved in aptients with ,head injury and encephalitis. Although the ultimate outcome was not altered in patients with stroke or near-drowning, intracranial hypertension did not occur until barbiturate therapy was withdrawn. This experience provides an ethical basis to justify further randomized studies for determining whether or not barbiturates materially improve the neurological outcome following cerebral ischemic and traumatic insults.
M A Rockoff; L F Marshall; H M Shapiro
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of neurology     Volume:  6     ISSN:  0364-5134     ISO Abbreviation:  Ann. Neurol.     Publication Date:  1979 Sep 
Date Detail:
Created Date:  1980-03-17     Completed Date:  1980-03-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7707449     Medline TA:  Ann Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  194-9     Citation Subset:  IM    
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MeSH Terms
Barbiturates / administration & dosage*,  therapeutic use
Brain Diseases / drug therapy*
Brain Injuries / drug therapy*
Brain Ischemia / drug therapy
Cerebrovascular Disorders / drug therapy
Child, Preschool
Dosage Forms
Encephalitis / drug therapy
Hypoxia, Brain / drug therapy
Middle Aged
Reg. No./Substance:
0/Barbiturates; 0/Dosage Forms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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