| High dose of ascorbic acid induces cell death in mesothelioma cells. | |
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MedLine Citation:
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PMID: 20171954 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Malignant mesothelioma is an asbestos-related fatal disease with no effective cure. Recently, high dose of ascorbate in cancer treatment has been reexamined. We studied whether high dose of ascorbic acid induced cell death of four human mesothelioma cell lines. High dose of ascorbic acid induced cell death of all mesothelioma cell lines in a dose-dependent manner. We further clarified the cell killing mechanism that ascorbic acid induced reactive oxygen species and impaired mitochondrial membrane potential. In vivo experiment, intravenous administration of ascorbic acid significantly decreased the growth rate of mesothelioma tumor inoculated in mice. These data suggest that ascorbic acid may have benefits for patients with mesothelioma. |
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Authors:
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Yukitoshi Takemura; Motohiko Satoh; Kiyotoshi Satoh; Hironobu Hamada; Yoshitaka Sekido; Shunichiro Kubota |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-02-19 |
Journal Detail:
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Title: Biochemical and biophysical research communications Volume: 394 ISSN: 1090-2104 ISO Abbreviation: Biochem. Biophys. Res. Commun. Publication Date: 2010 Apr |
Date Detail:
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Created Date: 2010-04-05 Completed Date: 2010-04-22 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0372516 Medline TA: Biochem Biophys Res Commun Country: United States |
Other Details:
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Languages: eng Pagination: 249-53 Citation Subset: IM |
Copyright Information:
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2010 Elsevier Inc. All rights reserved. |
Affiliation:
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Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, 3-8-1 Komaba, Meguro-ku, Tokyo 153-8902, Japan. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis* Ascorbic Acid / administration & dosage* Cell Line, Tumor Cell Proliferation / drug effects Humans Membrane Potential, Mitochondrial / drug effects Mesothelioma / drug therapy* Mice Mice, SCID Reactive Oxygen Species / metabolism Xenograft Model Antitumor Assays |
| Chemical | |
Reg. No./Substance:
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0/Reactive Oxygen Species; 50-81-7/Ascorbic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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