| High-dose ascorbic acid decreases cholesterolemic factors of an atherogenic diet in guinea pigs. | |
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MedLine Citation:
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PMID: 17896585 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: The study evaluates the effect of a high supplemental dose of ascorbic acid (AA) on plasma concentrations of total cholesterol (TC), triglycerides (TG), total lipids (TL), and lipoprotein fractions high-density, very-low-density-, and low-density lipoprotein (HDL, VLDL, LDL) in guinea pigs fed with atherogenic diet. METHODS: Group I consisted of 5 normally fed guinea pigs plus a low dose of AA (1 mg/100 g/day), group II consisted of 7 guinea pigs fed with food enriched with 2% cholesterol plus a low dose of AA (1 mg/100 g/day), and group III consisted of 7 guinea pigs fed with food enriched with 2% cholesterol plus a high dose of AA (30 mg/100 g/day). Cholesterolemic factors concentrations were determined after nine weeks. RESULTS: Concentrations of TC, TG, TL, LDL, and VLDL were increased in group II compared to group I (p < 0.01 for all differences). Supplementation with a high dose of AA resulted in decreased concentrations of TC (p < 0.01), TG (p < 0.01), TL (p < 0.01), and LDL (p < 0.01) in group III compared to group II. Additionally, concentration of HDL was increased in group III compared to group II (p < 0.01). CONCLUSION: High-dose AA supplementation to an atherogenic diet decreases concentrations of TC, TG, TL, and LDL and increases concentration of HDL compared to low-dose AA. |
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Authors:
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Konstantinos Filis; Aikaterini Anastassopoulou; Fragiska Sigala; Dimitrios Theodorou; Andreas Manouras; Emanouel Leandros; Panagiotis Sigalas; Wolfgang Hepp; John Bramis |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: International journal for vitamin and nutrition research. Internationale Zeitschrift für Vitamin- und Ernährungsforschung. Journal international de vitaminologie et de nutrition Volume: 77 ISSN: 0300-9831 ISO Abbreviation: Int J Vitam Nutr Res Publication Date: 2007 Mar |
Date Detail:
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Created Date: 2007-09-27 Completed Date: 2007-11-05 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 1273304 Medline TA: Int J Vitam Nutr Res Country: Switzerland |
Other Details:
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Languages: eng Pagination: 125-9 Citation Subset: IM |
Affiliation:
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First Department of Propedeutic Surgery, University of Athens Medical School, Athens, Greece. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Ascorbic Acid / pharmacology* Cholesterol / administration & dosage, blood Diet, Atherogenic* Dietary Supplements Dose-Response Relationship, Drug Guinea Pigs Hypercholesterolemia / prevention & control* Lipids / blood Lipoproteins / blood, drug effects Male Risk Factors Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Lipids; 0/Lipoproteins; 0/Triglycerides; 50-81-7/Ascorbic Acid; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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