| High-dose antioxidant supplements and cognitive function in community-dwelling elderly women. | |
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MedLine Citation:
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PMID: 12663300 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Experimental data suggest that oxygen free radicals are probably involved in the deterioration of cognitive processes. OBJECTIVE: Our objective was to investigate the relation of high-dose antioxidant supplements to cognition. DESIGN: Information on the use of specific supplements containing vitamins E and C was collected biennially via mailed questionnaires beginning in 1980 from 14 968 community-dwelling women who participated in the Nurses' Health Study. From 1995 to 2000, telephone tests of cognitive function [Telephone Interview of Cognitive Status (TICS), delayed recall of the TICS 10-word list, immediate and delayed recall of a short paragraph, a test of verbal fluency, and a digit span backwards test] were administered to the women, who were 70-79 y of age at that time. We used linear and logistic regression models to calculate multivariate-adjusted mean differences in test scores and relative risks of a low score for specific supplement users compared with nonusers. RESULTS: Long-term, current users of vitamin E with vitamin C had significantly better mean performance, as judged by a global score that combined individual test scores, than did women who had never used vitamin E or C (P = 0.03); there was a trend for increasingly higher mean scores with increasing durations of use (P = 0.04). These associations were strongest among women with low dietary intakes of alpha-tocopherol. Benefits were less consistent for women taking vitamin E alone, with no evidence of higher scores with longer durations of use. Use of specific vitamin C supplements alone had little relation to performance on our cognitive tests. CONCLUSION: The use of specific vitamin E supplements, but not specific vitamin C supplements, may be related to modest cognitive benefits in older women. |
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Authors:
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Francine Grodstein; Jennifer Chen; Walter C Willett |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 77 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2003 Apr |
Date Detail:
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Created Date: 2003-03-28 Completed Date: 2003-04-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 975-84 Citation Subset: AIM; IM |
Affiliation:
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Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA. fran.grodstein@channing.harvard.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Antioxidants / administration & dosage* Ascorbic Acid / administration & dosage Cognition* Cognition Disorders / diagnosis Cohort Studies Diet Dietary Supplements Female Health Surveys Humans Logistic Models Nurses Risk Telephone Vitamin E / administration & dosage alpha-Tocopherol / administration & dosage |
| Grant Support | |
ID/Acronym/Agency:
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AG13483/AG/NIA NIH HHS; AG15424/AG/NIA NIH HHS; CA87969/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 59-02-9/alpha-Tocopherol |
| Comments/Corrections | |
Comment In:
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Am J Clin Nutr. 2003 Apr;77(4):762-3
[PMID:
12663269
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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