Document Detail

High-dose adrenaline with low systemic vascular resistance and symmetrical peripheral gangrene.
MedLine Citation:
PMID:  8764956     Owner:  NLM     Status:  MEDLINE    
Symmetrical peripheral gangrene (SPG) is an uncommon syndrome consisting of distal ischaemic damage in two or more extremities, without large-vessel obstruction. We describe its development in the presence of a high cardiac and low systemic vascular resistance in a patient who was on high-dose adrenaline. With palpable radial and popliteal pulses the patient's hands and feet became dusky. This progressed to SPG. A sudden increase in serum lactate to high levels, noted in this case, may mark the onset of SPG.
G Joynt; L Doedens; J Lipman; P Bothma
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  South African journal of surgery. Suid-Afrikaanse tydskrif vir chirurgie     Volume:  34     ISSN:  0038-2361     ISO Abbreviation:  S Afr J Surg     Publication Date:  1996 May 
Date Detail:
Created Date:  1996-11-19     Completed Date:  1996-11-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  2984854R     Medline TA:  S Afr J Surg     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  99-101     Citation Subset:  IM    
Intensive Care Unit, Baragwanath Hospital, Johannesburg.
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MeSH Terms
Cardiac Output*
Epinephrine / administration & dosage,  adverse effects*
Gangrene / etiology*
Hypotension / drug therapy
Lactic Acid / blood
Malaria, Falciparum / blood,  complications
Vascular Resistance*
Vasoconstrictor Agents / administration & dosage,  adverse effects*
Reg. No./Substance:
0/Vasoconstrictor Agents; 50-21-5/Lactic Acid; 51-43-4/Epinephrine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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