Document Detail

High-dose dexmedetomidine-induced hypertension in a child with traumatic brain injury.
MedLine Citation:
PMID:  18491236     Owner:  NLM     Status:  MEDLINE    
INTRODUCTION: Dexmedetomidine is a centrally acting alpha(2)-adrenergic agonist which is currently FDA-approved for the short-term (less than 24 h) sedation of adults during mechanical ventilation. DISCUSSION: Given its beneficial physiologic properties, there has been increasing use of this agent in the pediatric population. As with any agent used for sedation in the Pediatric ICU setting, dose escalations may be necessary. Unlike benzodiazepines and opioids, there are limited data regarding the administration of dexmedetomidine above the current package insert dosing recommendations of 0.7 microg/kg/h. RESULTS: We report a 2-year-old child with traumatic brain injury who developed hypertension following the administration of a dexmedetomidine infusion at 4 microg/kg/h for several hours. Investigation into the etiology of the hypertension was negative and the blood pressure returned to baseline with a decrease in the infusion rate. CONCLUSION: Subsequent to this, no further issues with hypertension were noted.
Gwen Erkonen; Fred Lamb; Joseph D Tobias
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Neurocritical care     Volume:  9     ISSN:  1541-6933     ISO Abbreviation:  Neurocrit Care     Publication Date:  2008  
Date Detail:
Created Date:  2008-10-31     Completed Date:  2009-01-27     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101156086     Medline TA:  Neurocrit Care     Country:  United States    
Other Details:
Languages:  eng     Pagination:  366-9     Citation Subset:  IM    
Department of Pediatrics, University of Iowa, Iowa City, IA, USA.
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MeSH Terms
Brain Injuries / therapy*
Child, Preschool
Dexmedetomidine / administration & dosage*,  adverse effects*
Dose-Response Relationship, Drug
Hypertension / chemically induced*
Hypnotics and Sedatives / administration & dosage*,  adverse effects*
Reg. No./Substance:
0/Hypnotics and Sedatives; 113775-47-6/Dexmedetomidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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