Document Detail


High dose CART peptide induces abnormal EEG activity and behavioral seizures.
MedLine Citation:
PMID:  18178249     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Cocaine- and amphetamine-regulated transcript (CART) peptides are neurotransmitters found throughout the nervous system and in the periphery. CART has an important role in the regulation of food intake, anxiety, endocrine function, and in mesolimbic-mediated reward and reinforcement. This short report casts light upon previous descriptions of presumed behavioral seizure and tremor activity following administration of CART into the central nervous system. By employing electroencephalographic (EEG) recordings, we document the state of cerebrocortical activity. We find that intracerebroventricular (icv) administration of 5 microg of CART 55-102 readily produces an abnormal EEG characterized initially by high amplitude hypersynchronous alpha in the 8-10 Hz range during behavioral wakefulness as manifest in both cortical and hippocampal theta EEG channels. This reliably progressed in three of three animals tested to unequivocal epileptiform activity accompanied by tremors and assumption of a rigid, tonic body posture. The neural substrates underlying this finding are unclear. This novel description of the epileptogenic quality of CART should lend caution to interpretations of the behaviors attributed to CART in other experimental paradigms.
Authors:
Glenda L Keating; Michael J Kuhar; David B Rye
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural     Date:  2008-02-21
Journal Detail:
Title:  Neuropeptides     Volume:  42     ISSN:  0143-4179     ISO Abbreviation:  Neuropeptides     Publication Date:  2008 Apr 
Date Detail:
Created Date:  2008-03-07     Completed Date:  2008-06-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8103156     Medline TA:  Neuropeptides     Country:  Scotland    
Other Details:
Languages:  eng     Pagination:  199-204     Citation Subset:  IM    
Affiliation:
Department of Neurology, Emory University School of Medicine, 101 Woodruff Circle, Suite 6000, WMB, Atlanta, GA 30322, USA. gkeatin@emory.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Behavior, Animal / drug effects
Dopamine / physiology
Dose-Response Relationship, Drug
Electroencephalography / drug effects*
Epilepsy / chemically induced*
Injections, Intraventricular
Male
Nerve Tissue Proteins / toxicity*
Rats
Rats, Sprague-Dawley
Grant Support
ID/Acronym/Agency:
DA00418/DA/NIDA NIH HHS; DA10732/DA/NIDA NIH HHS; DA15162/DA/NIDA NIH HHS; NS055015/NS/NINDS NIH HHS; RR000165/RR/NCRR NIH HHS
Chemical
Reg. No./Substance:
0/Nerve Tissue Proteins; 0/cocaine- and amphetamine-regulated transcript protein

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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