Document Detail

High dosage tobramycin treatment of children with cystic fibrosis. Bacteriological effect and clinical ototoxicity.
MedLine Citation:
PMID:  553884     Owner:  NLM     Status:  MEDLINE    
The bacteriological effect of chemotherapy against mucoid strains of Pseudominas aeruginosa in the lower respiratory tract of patients with cystic fibrosis is reported. A comparison of the effect of high doses of tobramycin (10 mg/kg/24 h) given alone or in combination with carbenicillin showed a significant difference in favour of the combination therapy. In 74.5% of the initially successful courses the patients were recolonized within one month. Fifty-three patients were examined by audiometric and vestibular tests. Only in one patient was it possible to register a transient, high tone hearing impairment at 8000 Hz bilaterally, that might be attributed to the tobramycin treatment. It is concluded that high dose tobramycin treatment in children and adolescents with normal kidney function implies only a minimal clinical risk of adverse ototoxic effects, even after repeated courses of treatment. No nephrotoxic side-effects were found in this material.
J Thomsen; B Friis
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of pediatric otorhinolaryngology     Volume:  1     ISSN:  0165-5876     ISO Abbreviation:  Int. J. Pediatr. Otorhinolaryngol.     Publication Date:  1979 Jul 
Date Detail:
Created Date:  1981-03-17     Completed Date:  1981-03-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003603     Medline TA:  Int J Pediatr Otorhinolaryngol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  33-40     Citation Subset:  IM    
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MeSH Terms
Anti-Bacterial Agents / administration & dosage*
Carbenicillin / administration & dosage
Cystic Fibrosis / complications*
Drug Therapy, Combination
Pseudomonas Infections / complications,  drug therapy*,  microbiology
Respiratory Tract Infections / complications,  drug therapy*,  microbiology
Tobramycin / administration & dosage*,  adverse effects
Reg. No./Substance:
0/Anti-Bacterial Agents; 32986-56-4/Tobramycin; 4697-36-3/Carbenicillin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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