Document Detail

High dissociation constants (pKa) of basic permeants are associated with in vivo skin irritation in man.
MedLine Citation:
PMID:  8730159     Owner:  NLM     Status:  MEDLINE    
Previously, we have investigated the relationship between dissociation constant (pKa) and skin irritation potential. In the present experiment, 12 basic compounds, with varying pKa values ranging from 1.4 to 11.2, were applied on the backs of 12 healthy adult panellists. Cutaneous reactions were measured objectively, using reflectance spectroscopy and transepidermal water loss (TEWL), and evaluated subjectively with a modified Draize scale. A positive correlation between increasing pKa and skin irritation capacity, measured either visually or by reflectance spectroscopy, was found, but only mecamylamine (pKa = 11.2) induced a significant increase in transepidermal water loss. Compounds with low pKa also induced a paradoxical vasoconstriction measured by reflectance spectroscopy. Only high pKa appeared predictive of in vivo skin irritation, and these chemicals apparently induce skin irritation with only minimal disruption of the skin barrier. A simple 1-variable model is predictive of skin irritation for this series of organic permeants with increasing pKa.
A Nangia; P H Andersen; B Berner; H I Maibach
Related Documents :
14690379 - Reactions of anthocyanins and tannins in model solutions.
23154219 - Watching a food-related television show and caloric intake: a laboratory study.
6378969 - Evaluation of a microtiter system for identification of anaerobic bacteria.
20525119 - Food-dependent exercise-induced anaphylaxis: a case related to chickpea ingestion and r...
1510289 - Buckwheat-induced anaphylaxis: a case report.
10442479 - Enteral histaminosis: clinical implications.
19767079 - Associations of functional nlrp3 polymorphisms with susceptibility to food-induced anap...
15473149 - Risk factors for transmission of foodborne illness in restaurants and street vendors in...
25254209 - Origanum dictamnus oil vapour suppresses the development of grey mould in eggplant frui...
Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Contact dermatitis     Volume:  34     ISSN:  0105-1873     ISO Abbreviation:  Contact Derm.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-09-17     Completed Date:  1996-09-17     Revised Date:  2006-09-18    
Medline Journal Info:
Nlm Unique ID:  7604950     Medline TA:  Contact Dermatitis     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  237-42     Citation Subset:  IM    
Glaxo Canada, Toronto, Canada.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cell Membrane Permeability / drug effects
Dermatitis, Irritant / etiology*,  metabolism
Hemoglobins / metabolism
Hydrogen-Ion Concentration
Irritants / adverse effects*,  chemistry*
Middle Aged
Patch Tests
Skin / drug effects,  metabolism
Skin Absorption / drug effects
Water Loss, Insensible / drug effects,  physiology
Reg. No./Substance:
0/Hemoglobins; 0/Irritants

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Loss of contact sensitization evaluated by laser Doppler blood flowmetry and transepidermal water lo...
Next Document:  Development of hand eczema in junior hairdressers: an 8-year follow-up study.