Document Detail

High-dimensional time irreversibility analysis of human interbeat intervals.
MedLine Citation:
PMID:  21276744     Owner:  NLM     Status:  Publisher    
Time irreversibility is a subject of increasing interest in biomedicine. However, measurements of this property have been limited to a two-dimensional state space and few effective methods for high-dimensional time irreversibility testing have been reported. Using a strategy based on multiple bidimensional tests, we propose an extension of the traditional low-dimensional method for the estimation of time irreversibility in a high-dimensional state space. The method is applied to both physiological and synthetic interbeat (RR) intervals and the results indicate that time irreversibility should be an intrinsic characteristic of human RR intervals and is complementary to the conventional properties that can be measured in the time and frequency domain. Furthermore, a loss of time irreversibility is detected when the method is applied to patients with congestive heart failure (CHF). Compared with the traditional time irreversibility test, the proposed method is not only capable of quantifying time irreversibility in a more reliable manner, but is also effective for analysis of short records of only a few minutes' length, which would be more useful clinically.
Feng Zhen Hou; Xin Bao Ning; Jian Jun Zhuang; Xiao Lin Huang; Mao Jing Fu; Chun Hua Bian
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-1-26
Journal Detail:
Title:  Medical engineering & physics     Volume:  -     ISSN:  1873-4030     ISO Abbreviation:  -     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-1-31     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9422753     Medline TA:  Med Eng Phys     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 IPEM. Published by Elsevier Ltd. All rights reserved.
Key Laboratory of Modern Acoustics, School of Electronic Science & Engineering, Institute for Biomedical Electronic Engineering, Nanjing University, Nanjing 210093, China; Information Management Teaching and Research Center, Department of Basic Science, China Pharmaceutical University, Nanjing 210009, China.
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