Document Detail

High dietary antioxidant intakes are associated with decreased chromosome translocation frequency in airline pilots.
MedLine Citation:
PMID:  19793852     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Dietary antioxidants may protect against DNA damage induced by endogenous and exogenous sources, including ionizing radiation (IR), but data from IR-exposed human populations are limited.
OBJECTIVE: The objective was to examine the association between the frequency of chromosome translocations, as a biomarker of cumulative DNA damage, and intakes of vitamins C and E and carotenoids in 82 male airline pilots.
DESIGN: Dietary intakes were estimated by using a self-administered semiquantitative food-frequency questionnaire. Translocations were scored by using fluorescence in situ hybridization with whole chromosome paints. Negative binomial regression was used to estimate rate ratios and 95% CIs, adjusted for potential confounders.
RESULTS: Significant and inverse associations were observed between translocation frequency and intakes of vitamin C, beta-carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food (P < 0.05). Translocation frequency was not associated with the intake of vitamin E, alpha-carotene, or lycopene from food; total vitamin C or E from food and supplements; or vitamin C or E or multivitamin supplements. The adjusted rate ratios (95% CI) for > or =median compared with <median servings per week of high-vitamin C fruit and vegetables, citrus fruit, and green leafy vegetables were 0.61 (0.43, 0.86), 0.64 (0.46, 0.89), and 0.59 (0.43, 0.81), respectively. The strongest inverse association was observed for > or =median compared with <median combined intakes of vitamins C and E, beta-carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food: 0.27 (0.14, 0.55).
CONCLUSION: High combined intakes of vitamins C and E, beta-carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food, or a diet high in their food sources, may protect against cumulative DNA damage in IR-exposed persons.
Lee C Yong; Martin R Petersen; Alice J Sigurdson; Laura A Sampson; Elizabeth M Ward
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, P.H.S.     Date:  2009-09-30
Journal Detail:
Title:  The American journal of clinical nutrition     Volume:  90     ISSN:  1938-3207     ISO Abbreviation:  Am. J. Clin. Nutr.     Publication Date:  2009 Nov 
Date Detail:
Created Date:  2009-10-21     Completed Date:  2010-01-06     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0376027     Medline TA:  Am J Clin Nutr     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1402-10     Citation Subset:  AIM; IM    
National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA.
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MeSH Terms
Administration, Oral
Antioxidants / administration & dosage,  pharmacology*
Ascorbic Acid / pharmacology
Carotenoids / administration & dosage,  pharmacology
Chromosomes, Human / drug effects,  genetics
Dietary Supplements
Interviews as Topic
Translocation, Genetic / drug effects*
Vitamin E / pharmacology
beta Carotene / administration & dosage
Grant Support
Reg. No./Substance:
0/Antioxidants; 1406-18-4/Vitamin E; 36-88-4/Carotenoids; 45XWE1Z69V/alpha-carotene; 50-81-7/Ascorbic Acid; 7235-40-7/beta Carotene

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