| High dietary antioxidant intakes are associated with decreased chromosome translocation frequency in airline pilots. | |
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MedLine Citation:
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PMID: 19793852 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Dietary antioxidants may protect against DNA damage induced by endogenous and exogenous sources, including ionizing radiation (IR), but data from IR-exposed human populations are limited. OBJECTIVE: The objective was to examine the association between the frequency of chromosome translocations, as a biomarker of cumulative DNA damage, and intakes of vitamins C and E and carotenoids in 82 male airline pilots. DESIGN: Dietary intakes were estimated by using a self-administered semiquantitative food-frequency questionnaire. Translocations were scored by using fluorescence in situ hybridization with whole chromosome paints. Negative binomial regression was used to estimate rate ratios and 95% CIs, adjusted for potential confounders. RESULTS: Significant and inverse associations were observed between translocation frequency and intakes of vitamin C, beta-carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food (P < 0.05). Translocation frequency was not associated with the intake of vitamin E, alpha-carotene, or lycopene from food; total vitamin C or E from food and supplements; or vitamin C or E or multivitamin supplements. The adjusted rate ratios (95% CI) for > or =median compared with <median servings per week of high-vitamin C fruit and vegetables, citrus fruit, and green leafy vegetables were 0.61 (0.43, 0.86), 0.64 (0.46, 0.89), and 0.59 (0.43, 0.81), respectively. The strongest inverse association was observed for > or =median compared with <median combined intakes of vitamins C and E, beta-carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food: 0.27 (0.14, 0.55). CONCLUSION: High combined intakes of vitamins C and E, beta-carotene, beta-cryptoxanthin, and lutein-zeaxanthin from food, or a diet high in their food sources, may protect against cumulative DNA damage in IR-exposed persons. |
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Authors:
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Lee C Yong; Martin R Petersen; Alice J Sigurdson; Laura A Sampson; Elizabeth M Ward |
Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Intramural; Research Support, U.S. Gov't, P.H.S. Date: 2009-09-30 |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 90 ISSN: 1938-3207 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-21 Completed Date: 2010-01-06 Revised Date: 2013-05-31 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 1402-10 Citation Subset: AIM; IM |
Affiliation:
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National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH 45226, USA. lay7@cdc.gov |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Administration, Oral Aircraft Antioxidants / administration & dosage, pharmacology* Ascorbic Acid / pharmacology Carotenoids / administration & dosage, pharmacology Chromosomes, Human / drug effects, genetics Dietary Supplements Fruit Humans Interviews as Topic Male Occupations* Questionnaires Translocation, Genetic / drug effects* Vegetables Vitamin E / pharmacology beta Carotene / administration & dosage |
| Grant Support | |
ID/Acronym/Agency:
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Y1CP802904/CP/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Antioxidants; 1406-18-4/Vitamin E; 36-88-4/Carotenoids; 45XWE1Z69V/alpha-carotene; 50-81-7/Ascorbic Acid; 7235-40-7/beta Carotene |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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