| High density lipoprotein: it's not just about lipid transport anymore. | |
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MedLine Citation:
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PMID: 21067941 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Plasma levels of high density lipoprotein cholesterol (HDL-C) have long been associated with protection against cardiovascular disease (CVD) in large populations. However, HDL-C has been significantly less useful for predicting CVD risk in individual patients. This has ignited a new debate on the merits of measuring HDL quantity versus quality in terms of protective potential. In addition, numerous recent studies have begun to uncover HDL functions that vary surprisingly from traditional lipid transport roles. In this paper, we review recent findings that point to important functions for HDL that go well beyond lipid transport. These discoveries suggest that HDL might be a platform that mediates protection from a host of disease states ranging from CVD to diabetes to infectious disease. |
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Authors:
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Scott M Gordon; Susanna Hofmann; David S Askew; W Sean Davidson |
Publication Detail:
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Type: Journal Article; Review Date: 2010-11-08 |
Journal Detail:
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Title: Trends in endocrinology and metabolism: TEM Volume: 22 ISSN: 1879-3061 ISO Abbreviation: Trends Endocrinol. Metab. Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2010-12-28 Completed Date: 2011-04-26 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 9001516 Medline TA: Trends Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 9-15 Citation Subset: IM |
Affiliation:
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Center for Lipid and Arteriosclerosis Science, University of Cincinnati, 2120 East Galbraith Road, Cincinnati, OH 45237-0507, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Transport / physiology Cardiovascular Diseases / metabolism Cholesterol, HDL / genetics, metabolism* Embryonic Development / physiology Humans Immunity, Innate / immunology Models, Biological |
| Grant Support | |
ID/Acronym/Agency:
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R01 HL062542-10/HL/NHLBI NIH HHS; R01 HL067093-09/HL/NHLBI NIH HHS; R21 HL104136-01/HL/NHLBI NIH HHS; R21 HL104136-02/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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