Document Detail


High-density lipoprotein function, dysfunction, and reverse cholesterol transport.
MedLine Citation:
PMID:  23152494     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Although high high-density lipoprotein (HDL)-cholesterol levels are associated with decreased cardiovascular risk in epidemiological studies, recent genetic and pharmacological findings have raised doubts about the beneficial effects of HDL. Raising HDL levels in animal models by infusion or overexpression of apolipoprotein A-I has shown clear vascular improvements, such as delayed atherosclerotic lesion progression and accelerated lesion regression, along with increased reverse cholesterol transport. Inflammation and other factors, such as myeloperoxidase-mediated oxidation, can impair HDL production and HDL function, with regard to its reverse cholesterol transport, antioxidant, and anti-inflammatory activities. Thus, tests of HDL function, which have not yet been developed as routine diagnostic assays, may prove useful and be a better predictor of cardiovascular risk than HDL-cholesterol levels.
Authors:
Edward A Fisher; Jonathan E Feig; Bernd Hewing; Stanley L Hazen; Jonathan D Smith
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Arteriosclerosis, thrombosis, and vascular biology     Volume:  32     ISSN:  1524-4636     ISO Abbreviation:  Arterioscler. Thromb. Vasc. Biol.     Publication Date:  2012 Dec 
Date Detail:
Created Date:  2012-11-15     Completed Date:  2013-01-29     Revised Date:  2014-03-19    
Medline Journal Info:
Nlm Unique ID:  9505803     Medline TA:  Arterioscler Thromb Vasc Biol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2813-20     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Apolipoprotein A-I / physiology
Atherosclerosis / metabolism,  physiopathology*
Biological Transport / physiology
Cardiovascular Diseases / epidemiology*
Cholesterol / metabolism*
Disease Progression*
Humans
Lipoproteins, HDL / physiology*
Models, Animal
Risk Factors
Grant Support
ID/Acronym/Agency:
P01 HL098055/HL/NHLBI NIH HHS; P01 HL098055/HL/NHLBI NIH HHS; T32 GM007308/GM/NIGMS NIH HHS
Chemical
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Lipoproteins, HDL; 97C5T2UQ7J/Cholesterol
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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