Document Detail


High-density lipoprotein cholesterol and triglyceride response with simvastatin versus atorvastatin in familial hypercholesterolemia.
MedLine Citation:
PMID:  11009276     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The clinical and biochemical determinants of high-density lipoprotein (HDL) and triglyceride response to simvastatin and atorvastatin were assessed in 150 patients with severe hyperlipidemia treated in a randomized open-trial format design. Triglyceride reduction was only dependent on HDL:apolipoprotein A1, change in apolipoprotein B, and dose response, whereas an increase in HDL was dependent on initial LDL, change in LDL or dose response, and therapy with simvastatin.
Authors:
A S Wierzbicki; P J Lumb; G Chik; M A Crook
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  The American journal of cardiology     Volume:  86     ISSN:  0002-9149     ISO Abbreviation:  Am. J. Cardiol.     Publication Date:  2000 Sep 
Date Detail:
Created Date:  2000-10-05     Completed Date:  2000-10-05     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0207277     Medline TA:  Am J Cardiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  547-9, A9     Citation Subset:  AIM; IM    
Affiliation:
Department of Chemical Pathology, King's College London, Guy's, King's & St Thomas' Medical School, United Kingdom. Anthony.Wierzbicki@kcl.ac.uk
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MeSH Terms
Descriptor/Qualifier:
Anticholesteremic Agents / therapeutic use*
Cholesterol, HDL / blood*
Cross-Over Studies
Female
Heptanoic Acids / therapeutic use*
Humans
Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use*
Hyperlipidemias / blood,  drug therapy
Hyperlipoproteinemia Type II / blood,  drug therapy*
Male
Middle Aged
Pyrroles / therapeutic use*
Regression Analysis
Simvastatin / therapeutic use*
Triglycerides / blood*
Chemical
Reg. No./Substance:
0/Anticholesteremic Agents; 0/Cholesterol, HDL; 0/Heptanoic Acids; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Pyrroles; 0/Triglycerides; 110862-48-1/atorvastatin; 79902-63-9/Simvastatin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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