Document Detail


High-density lipoprotein cholesterol levels increase with age, body mass index, blood pressure and fasting blood glucose in a rural Uygur population in China.
MedLine Citation:
PMID:  16208139     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To investigate the distribution of the serum high-density lipoprotein cholesterol (HDLC) levels and its relationship with obesity, hypertension and diabetes in a Uygur case-control study on hypertension. DESIGN: A case-control (339 hypertensive cases, 272 normotensive controls) study on hypertension was conducted, and obesity, hypertension, lipid profiles and fasting blood glucose were analyzed. METHODS: The demographic data, history of disease and lifestyles, including diet, smoking and salt intake, were recorded and three measurements of blood pressure were obtained by trained observers. The fasting serum lipid profiles and glucose were determined. RESULTS: The HDLC levels of hypertensive participants were significantly higher than normotensive participants after adjustment for age and gender (1.145 versus 1.117 mmol/l, P = 0.001, power = 0.867). After adjustment for related variables, the HDLC levels slightly increased with age, body mass index and fasting glucose (all P = 0.001, power > 0.80) in normotensive participants and only increased with age among hypertensive participants (P = 0.0001, power = 0.971). CONCLUSIONS: The serum HDLC levels in Uygur normotensive participants increased with age, body mass index, blood pressure and fasting glucose levels. This was inconsistent with the previous studies and the reason remained unclear. Further study is needed to elucidate both the environmental and genetic determinants of the novel distribution of the HDLC levels and their association with coronary heart disease in the Uygur population.
Authors:
Weili Yan; Dongfeng Gu; Xiaoyan Yang; Jun Wu; Ling Kang; Li Zhang
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of hypertension     Volume:  23     ISSN:  0263-6352     ISO Abbreviation:  J. Hypertens.     Publication Date:  2005 Nov 
Date Detail:
Created Date:  2005-10-06     Completed Date:  2006-02-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8306882     Medline TA:  J Hypertens     Country:  England    
Other Details:
Languages:  eng     Pagination:  1985-9     Citation Subset:  IM    
Affiliation:
Division of Environmental Health, School of Public Health, Xinjiang Medical University, Xinjiang Uygur Autonomous Region, China. yanweilli01@yahoo.com.cn
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Age Factors
Aged
Blood Glucose / metabolism*
Blood Pressure / physiology*
Body Mass Index*
Case-Control Studies
China
Cholesterol, HDL / blood*
Diabetes Mellitus / blood,  physiopathology
Fasting / blood
Female
Humans
Hypertension / blood,  physiopathology
Male
Middle Aged
Obesity / blood,  physiopathology
Rural Health
Chemical
Reg. No./Substance:
0/Blood Glucose; 0/Cholesterol, HDL

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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