Document Detail

High-density lipoprotein cholesterol and insulin resistance are independent and additive markers of left ventricular hypertrophy in essential hypertension.
MedLine Citation:
PMID:  17460382     Owner:  NLM     Status:  MEDLINE    
We examined whether plasma high-density lipoprotein-cholesterol (HDL-C) levels and glucose metabolism parameters are independent or additive predictors of left ventricular hypertrophy (LVH) in patients with untreated essential hypertension. The study group consisted of 41 Japanese patients with untreated essential hypertension and LVH (left ventricular mass index [LVMI] >125 g/m2; age 58+/-6 years, mean+/-SD), and the control group consisted of 39 age-matched patients with untreated essential hypertension without LVH (LVMI <or=125 g/m2; age 58+/-7 years). The following metabolic parameters were higher in the group with LVH: fasting plasma glucose (FPG) (p<0.01), fasting insulin concentration (F-IRI) (p<0.0001), and homeostasis model assessment (HOMA)-index (p<0.0001). Among the laboratory parameters investigated, plasma HDL-C levels were lower (p<0.0001), and triglyceride and uric acid levels were higher in the group with LVH (p<0.05 for both). The nighttime systolic and diastolic ambulatory blood pressure (ABP) (p<0.0001, p<0.01, respectively) and nighttime heart rate (p<0.01) were higher in patients with LVH. Multivariate logistic analysis identified HDL-C (odds ratio [OR]=0.92, 95% confidence interval [CI]=0.87-0.98, p<0.05), HOMA-index (OR=3.83, 95% CI=1.28-11.5, p<0.05) and nighttime systolic ambulatory blood pressure (ABP) (OR=1.06, 95% CI=1.00-1.13, p<0.05) as independent significant risk factors for LVH. Our findings suggest that HDL-C, HOMA-index and nighttime systolic ABP are independent predictors for the presence of LVH in Japanese patients with essential hypertension.
Futoshi Anan; Hidetoshi Yonemochi; Takayuki Masaki; Naohiko Takahashi; Naoya Fukunaga; Yasushi Teshima; Tetsu Iwao; Koji Kaneda; Nobuoki Eshima; Tetsunori Saikawa; Hironobu Yoshimatsu
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Hypertension research : official journal of the Japanese Society of Hypertension     Volume:  30     ISSN:  0916-9636     ISO Abbreviation:  Hypertens. Res.     Publication Date:  2007 Feb 
Date Detail:
Created Date:  2007-04-26     Completed Date:  2007-06-14     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9307690     Medline TA:  Hypertens Res     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  125-31     Citation Subset:  IM    
Department of Cardiovascular Science, Faculty of Medicine, Oita University, Japan.
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MeSH Terms
Biological Markers / blood
Blood Pressure Determination
Cholesterol, HDL / blood*
Hypertension / complications*
Hypertrophy, Left Ventricular / epidemiology*,  etiology,  ultrasonography
Insulin Resistance*
Middle Aged
Triglycerides / blood
Uric Acid / blood
Reg. No./Substance:
0/Biological Markers; 0/Cholesterol, HDL; 0/Triglycerides; 69-93-2/Uric Acid

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