Document Detail

High density lipoprotein cholesterol in male relatives of patients with coronary heart disease.
MedLine Citation:
PMID:  223587     Owner:  NLM     Status:  MEDLINE    
To study factors that play a role in the familial occurrence of coronary heart disease, very low density lipoprotein (VLDL) triglycerides, low density lipoprotein (LDL) cholesterol and high density lipoprotein (HDL) cholesterol were measured after preparative ultracentrifugation in first degree male relatives of coronary patients and in control subjects. The HDL cholesterol concentration was significantly lower in relatives of 20--71 years old than in controls. No increase of serum and LDL cholesterol was found. A low level of HDL cholesterol was observed even in the younger relatives who are less likely to have cardiovascualr disease. In older relatives low HDL cholesterol was found in the presence or absence of clinical evidence of coronary artery disease. The HDL-cholesterol concentration was inversely related to the VLDL triglycerides both in relatives and controls, but the regression lines were different ((P less than 0.001) for the relative (y = --0.166x + 0.43) and for the controls (y = 0.191x + 0.49). A low HDL cholesterol level appears to be a marker of relatives of coronary patients.
H Micheli; D Pometta; C Jornot; J R Scherrer
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Atherosclerosis     Volume:  32     ISSN:  0021-9150     ISO Abbreviation:  Atherosclerosis     Publication Date:  1979 Mar 
Date Detail:
Created Date:  1979-09-17     Completed Date:  1979-09-17     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0242543     Medline TA:  Atherosclerosis     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  269-76     Citation Subset:  IM    
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MeSH Terms
Cholesterol / blood*
Coronary Disease / blood*,  genetics
Lipoproteins, HDL / blood*
Lipoproteins, LDL / blood
Lipoproteins, VLDL / blood
Middle Aged
Myocardial Infarction / blood,  genetics
Triglycerides / blood
Reg. No./Substance:
0/Lipoproteins, HDL; 0/Lipoproteins, LDL; 0/Lipoproteins, VLDL; 0/Triglycerides; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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