| High density lipoprotein cholesterol and apolipoprotein A-I are persistently elevated during long-term treatment with pitavastatin, a new HMG-CoA reductase inhibitor. | |
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MedLine Citation:
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PMID: 19138801 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Although a low level of high density lipoprotein-cholesterol (HDL-C) is an important risk factor for coronary heart disease, few available agents are capable of significantly increasing HDL-C. This multicenter study demonstrated that administration of pitavastatin, a new HMG-CoA reductase inhibitor, significantly and persistently increased HDL-C (from 36.0+/-5.9 to 40.5+/-9.1 mg/dL: p<0.001) and apolipoprotein A-I levels (from 108.4+/-18.0 to 118.7+/-19.3 mg/dL: p<0.01) in 43 hypercholesterolemic patients with low HDL-C over the course of 12 months of treatment. This suggests that pitavastatin may contribute to reduction in coronary heart disease. |
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Authors:
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Tatsuya Fukutomi; Yutaka Takeda; Shogo Suzuki; Tatsuya Ito; Takashi Joh; Makoto Itoh |
Publication Detail:
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Type: Clinical Trial; Letter; Multicenter Study Date: 2009-01-12 |
Journal Detail:
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Title: International journal of cardiology Volume: 141 ISSN: 1874-1754 ISO Abbreviation: Int. J. Cardiol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-31 Completed Date: 2010-09-16 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8200291 Medline TA: Int J Cardiol Country: Netherlands |
Other Details:
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Languages: eng Pagination: 320-2 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2008 Elsevier Ireland Ltd. All rights reserved. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Aged Apolipoprotein A-I / blood* Cholesterol, HDL / blood* Coronary Disease / blood, drug therapy* Female Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors / therapeutic use* Hypercholesterolemia / blood, drug therapy* Male Middle Aged Quinolines / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-I; 0/Cholesterol, HDL; 0/Hydroxymethylglutaryl-CoA Reductase Inhibitors; 0/Quinolines; 147526-32-7/NK 104 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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