Document Detail

High-density lipoprotein affects antigen presentation by interfering with lipid raft: a promising anti-atherogenic strategy.
MedLine Citation:
PMID:  20059478     Owner:  NLM     Status:  MEDLINE    
Atherosclerosis is a chronic inflammatory disease. Immunomodulation of atherosclerosis emerges as a promising approach to prevention and treatment of this widely prevalent disease. The function of high-density lipoprotein (HDL) to promote reverse cholesterol transport may explain the ability of its protection against atherosclerosis. Findings that HDL and apolipoprotein A-I (apoA-I) inhibited the ability of antigen presenting cells (APCs) to stimulate T cells might be attributed to lipid raft, a cholesterol-rich microdomain exhibiting functional properties depending largely upon its lipid composition. Thus, modulating cholesterol in lipid raft may provide a promising anti-atherogenic strategy.
S-H Wang; S-G Yuan; D-Q Peng; S-P Zhao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2010-01-06
Journal Detail:
Title:  Clinical and experimental immunology     Volume:  160     ISSN:  1365-2249     ISO Abbreviation:  Clin. Exp. Immunol.     Publication Date:  2010 May 
Date Detail:
Created Date:  2010-07-15     Completed Date:  2010-08-16     Revised Date:  2013-05-31    
Medline Journal Info:
Nlm Unique ID:  0057202     Medline TA:  Clin Exp Immunol     Country:  England    
Other Details:
Languages:  eng     Pagination:  137-42     Citation Subset:  IM    
Department of Cardiology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
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MeSH Terms
Antigen Presentation / drug effects*,  physiology
Apolipoprotein A-I / physiology
Atherosclerosis / drug therapy,  etiology,  physiopathology,  prevention & control*
Autoimmune Diseases / drug therapy,  etiology,  physiopathology
Biological Transport / drug effects
Cholesterol / physiology
Disease Models, Animal
Histocompatibility Antigens Class II / immunology
Inflammation / complications,  drug therapy
Lipoproteins, HDL / pharmacology,  physiology*
Lymphocyte Activation / drug effects*
Membrane Lipids / physiology
Membrane Microdomains / drug effects*,  physiology
T-Lymphocyte Subsets / immunology*
Reg. No./Substance:
0/Apolipoprotein A-I; 0/Histocompatibility Antigens Class II; 0/Lipoproteins, HDL; 0/Membrane Lipids; 57-88-5/Cholesterol

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