| High-density lipoprotein affects antigen presentation by interfering with lipid raft: a promising anti-atherogenic strategy. | |
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MedLine Citation:
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PMID: 20059478 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Atherosclerosis is a chronic inflammatory disease. Immunomodulation of atherosclerosis emerges as a promising approach to prevention and treatment of this widely prevalent disease. The function of high-density lipoprotein (HDL) to promote reverse cholesterol transport may explain the ability of its protection against atherosclerosis. Findings that HDL and apolipoprotein A-I (apoA-I) inhibited the ability of antigen presenting cells (APCs) to stimulate T cells might be attributed to lipid raft, a cholesterol-rich microdomain exhibiting functional properties depending largely upon its lipid composition. Thus, modulating cholesterol in lipid raft may provide a promising anti-atherogenic strategy. |
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Authors:
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S-H Wang; S-G Yuan; D-Q Peng; S-P Zhao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2010-01-06 |
Journal Detail:
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Title: Clinical and experimental immunology Volume: 160 ISSN: 1365-2249 ISO Abbreviation: Clin. Exp. Immunol. Publication Date: 2010 May |
Date Detail:
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Created Date: 2010-07-15 Completed Date: 2010-08-16 Revised Date: 2011-07-28 |
Medline Journal Info:
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Nlm Unique ID: 0057202 Medline TA: Clin Exp Immunol Country: England |
Other Details:
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Languages: eng Pagination: 137-42 Citation Subset: IM |
Affiliation:
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Department of Cardiology, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antigen Presentation / drug effects*, physiology Apolipoprotein A-I / physiology Atherosclerosis / drug therapy, etiology, physiopathology, prevention & control* Autoimmune Diseases / drug therapy, etiology, physiopathology Biological Transport / drug effects Cholesterol / physiology Disease Models, Animal Histocompatibility Antigens Class II / immunology Humans Inflammation / complications, drug therapy Lipoproteins, HDL / pharmacology, physiology* Lymphocyte Activation / drug effects* Membrane Lipids / physiology Membrane Microdomains / drug effects*, physiology Mice T-Lymphocyte Subsets / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-I; 0/Histocompatibility Antigens Class II; 0/Lipoproteins, HDL; 0/Membrane Lipids; 57-88-5/Cholesterol |
| Comments/Corrections | |
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