Document Detail


High-density diffuse optical tomography of term infant visual cortex in the nursery.
MedLine Citation:
PMID:  23224175     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Advancements in antenatal and neonatal medicine over the last few decades have led to significant improvement in the survival rates of sick newborn infants. However, this improvement in survival has not been matched by a reduction in neurodevelopmental morbidities with increasing recognition of the diverse cognitive and behavioral challenges that preterm infants face in childhood. Conventional neuroimaging modalities, such as cranial ultrasound and magnetic resonance imaging, provide an important definition of neuroanatomy with recognition of brain injury. However, they fail to define the functional integrity of the immature brain, particularly during this critical developmental period. Diffuse optical tomography methods have established success in imaging adult brain function; however, few studies exist to demonstrate their feasibility in the neonatal population. We demonstrate the feasibility of using recently developed high-density diffuse optical tomography (HD-DOT) to map functional activation of the visual cortex in healthy term-born infants. The functional images show high contrast-to-noise ratio obtained in seven neonates. These results illustrate the potential for HD-DOT and provide a foundation for investigations of brain function in more vulnerable newborns, such as preterm infants.
Authors:
Steve M Liao; Silvina L Ferradal; Brian R White; Nicholas Gregg; Terrie E Inder; Joseph P Culver
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of biomedical optics     Volume:  17     ISSN:  1560-2281     ISO Abbreviation:  J Biomed Opt     Publication Date:  2012 Aug 
Date Detail:
Created Date:  2012-12-11     Completed Date:  2013-03-14     Revised Date:  2013-07-11    
Medline Journal Info:
Nlm Unique ID:  9605853     Medline TA:  J Biomed Opt     Country:  United States    
Other Details:
Languages:  eng     Pagination:  081414     Citation Subset:  IM    
Affiliation:
Washington University School of Medicine, Department of Pediatrics, 660 S. Euclid Ave, St. Louis, MO 63110, USA.
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MeSH Terms
Descriptor/Qualifier:
Algorithms*
Brain Mapping / methods*
Evoked Potentials, Visual / physiology*
Female
Humans
Image Enhancement / methods
Image Interpretation, Computer-Assisted / methods*
Imaging, Three-Dimensional / methods*
Infant, Newborn
Intensive Care, Neonatal / methods
Male
Pattern Recognition, Automated / methods*
Reproducibility of Results
Sensitivity and Specificity
Tomography, Optical / methods*
Visual Cortex / physiology*
Grant Support
ID/Acronym/Agency:
KL2 TR000450/TR/NCATS NIH HHS; KL2TR000450/TR/NCATS NIH HHS; R01 EB009233/EB/NIBIB NIH HHS; R01-EB009233/EB/NIBIB NIH HHS; R21 EB007924/EB/NIBIB NIH HHS; R21 HD057512/HD/NICHD NIH HHS; R21-EB007924/EB/NIBIB NIH HHS; T90-DA022871/DA/NIDA NIH HHS; UL1 RR024992/RR/NCRR NIH HHS; UL1RR0024992/RR/NCRR NIH HHS; UL1TR000448/TR/NCATS NIH HHS
Comments/Corrections

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