Document Detail

High cotinine levels are persistent during the first days of life in newborn second hand smokers.
MedLine Citation:
PMID:  24268547     Owner:  NLM     Status:  Publisher    
BACKGROUND: Despite the adverse effects of maternal smoking during pregnancy on the newborn's health are well-known, in the pediatric population, a high prevalence exists that is very much affected by second hand smoke (SHS). This study aims to investigate the impact of maternal smoking habits during pregnancy on cotinine levels in newborns during the first days of life. The high association between cotinine concentration in maternal and umbilical cord blood (UCB) has been previously reported, but the levels of blood cotinine that remain in infants born to smokers is unknown.
METHODS: Cotinine concentration was measured in UCB, in maternal and newborn peripheral blood. Data from UCB sample dyads of ninety mothers and from seventy-one newborns were analyzed.
RESULTS: Cotinine levels were significantly different among non-smokers (9.9±5.9ng/ml), moderate (67.3±7.4ng/ml), and heavy smokers (137.7±19.5ng/ml) (p<0.0001). Significant correlations were found between maternal and UCB cotinine (r=0.748; p<0.001), and between UCB and newborn plasma cotinine at 48h after birth (r=0.541; p<0.001). The smokers exposed their infants to cotinine with a median of 31.7±8.6ng/ml (moderate) or 59.1±13.3ng/ml (heavy smokers) until at least, 48h after birth. Reduced birth weight and length were significantly related with UCB cotinine levels.
CONCLUSIONS: A positive association between UCB and plasmatic cotinine in newborns was found. The high cotinine levels detected in newborns from smoker mothers indicates that their infants are subjected to elevated SHS from birth. These results can help to reinforce the awareness of the adverse effects of smoking during pregnancy.
Carmen Ivorra; Consuelo García-Vicent; Francisco Ponce; Graciela Ortega-Evangelio; José Antonio Fernández-Formoso; Empar Lurbe
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-10-31
Journal Detail:
Title:  Drug and alcohol dependence     Volume:  -     ISSN:  1879-0046     ISO Abbreviation:  Drug Alcohol Depend     Publication Date:  2013 Oct 
Date Detail:
Created Date:  2013-11-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7513587     Medline TA:  Drug Alcohol Depend     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.
Cardiovascular Risk Unit, Hospital General, University of Valencia, Department of Pediatrics, Avenida Tres Cruces 2, Valencia, 46014, Spain; CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, 28049, Spain. Electronic address:
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