Document Detail


High content of polyunsaturated fatty acids in muscle phospholipids of a fast runner, the European brown hare (Lepus europaeus).
MedLine Citation:
PMID:  13680130     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
To investigate both seasonal changes and possible intracorporal gradients of phospholipid fatty acid composition, skeletal muscles ( n=124), hearts ( n=27), and livers ( n=34) from free-living brown hares (Lepus europaeus) were analyzed. Phospholipids from both skeletal muscles and heart had a high degree of unsaturation with 66.8+/-0.63% and 65.7+/-0.5% polyunsaturated fatty acids, respectively. This is the highest proportion of polyunsaturated fatty acids reported in any mammalian tissue. Polyunsaturated fatty acid content in skeletal muscles was 2.3% greater in winter compared to summer (F(1,106)=17.7; P=0.0001), which may reflect thermoregulatory adjustments. Arachidonate (C20:4n-6) showed the greatest seasonal increase (+2.5%; F=7.95; P=0.0057). However, there were no pronounced differences in polyunsaturated fatty acid content between skeletal muscles from different locations in the body (m. iliopsoas, m. longissimus dorsi and m. vastus). Total muscle phospholipid polyunsaturated fatty acid content was correlated with polyunsaturated fatty acid content in triacyglycerols from perirenal white adipose tissue depots ( r(2)=0.61; P=0.004). Polyunsaturated fatty acids were enriched in muscle phospholipids (56.8-73.6%), compared to white adipose tissue lipids (20.9-61.2%), and liver phospholipids (25.1-54.2%). We suggest that the high degree of muscle membrane unsaturation is related to hare-specific traits, such as a high maximum running speed.
Authors:
T G Valencak; W Arnold; F Tataruch; T Ruf
Publication Detail:
Type:  Journal Article     Date:  2003-09-09
Journal Detail:
Title:  Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology     Volume:  173     ISSN:  0174-1578     ISO Abbreviation:  J. Comp. Physiol. B, Biochem. Syst. Environ. Physiol.     Publication Date:  2003 Nov 
Date Detail:
Created Date:  2003-11-17     Completed Date:  2004-07-08     Revised Date:  2009-06-08    
Medline Journal Info:
Nlm Unique ID:  8413200     Medline TA:  J Comp Physiol B     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  695-702     Citation Subset:  IM    
Affiliation:
Research Institute of Wildlife Ecology, University of Veterinary Medicine, Savoyenstrasse 1, 1160 Vienna, Austria.
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MeSH Terms
Descriptor/Qualifier:
Animals
Basal Metabolism
Fatty Acids / analysis
Fatty Acids, Unsaturated / analysis*
Muscle, Skeletal / chemistry*,  metabolism*
Phospholipids / analysis*
Rabbits / metabolism*
Running / physiology
Seasons
Chemical
Reg. No./Substance:
0/Fatty Acids; 0/Fatty Acids, Unsaturated; 0/Phospholipids

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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