| High concentration of peripheral blood mononuclear cells harboring infectious virus correlates with rapid progression of human immunodeficiency virus type 1-related diseases. | |
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MedLine Citation:
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PMID: 7901285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a cohort of 103 asymptomatic seropositive subjects (Centers for Disease Control and Prevention [CDC] stage II/III) followed for 2 years, the concentration of peripheral blood mononuclear cells harboring infectious human immunodeficiency virus (HIV) type 1 (viral burden) was correlated with the rate of decrease of CD4 cell count (RD-CD4; R = .857). Rapidly progressing patients (RD-CD4 > or = 60%; n = 18) had a high viral burden (mean +/- SE, 572 +/- 202 cells/mL) and an 89% progression to CDC IV-A-C, while stable patients (RD-CD4 < 30%; n = 55) had a low viral burden (mean +/- SE, 28 +/- 4 cells/mL) and remained asymptomatic. Slowly progressing patients (RD-CD4 > or = 30 and < 60%; n = 30) showed an intermediate viral burden (mean +/- SE, 131 +/- 9 cells/mL) and a 10% CDC IV-A-C progression. Quantitative determination of infectious virus in blood cells adds important information on the prognosis of HIV-1 infection. |
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Authors:
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W Lu; F Grassi; J M Tourani; D Eme; D Israel-Biet; J M Andrieu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of infectious diseases Volume: 168 ISSN: 0022-1899 ISO Abbreviation: J. Infect. Dis. Publication Date: 1993 Nov |
Date Detail:
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Created Date: 1993-11-29 Completed Date: 1993-11-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0413675 Medline TA: J Infect Dis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1165-8 Citation Subset: AIM; IM; X |
Affiliation:
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Laboratory of Tumor Immunology, Hôpital Laënnec, Université de Paris V, France. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult CD4-Positive T-Lymphocytes / microbiology* Cohort Studies Female HIV Seropositivity / blood, microbiology* HIV-1 / growth & development* Humans Leukocytes, Mononuclear / microbiology* Longitudinal Studies Male Middle Aged Prognosis |
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