Document Detail

High circulating levels of cytokines (IL-6 and TNFalpha), adhesion molecules (VCAM-1 and ICAM-1) and selectins in patients with peripheral arterial disease at rest and after a treadmill test.
MedLine Citation:
PMID:  12866607     Owner:  NLM     Status:  MEDLINE    
Peripheral arterial disease (PAD) is a common manifestation of atherosclerosis that is associated with systemic inflammation. The aim of our study was to assess whether plasma markers of inflammation increased after exercise in patients with PAD. The study was conducted on two groups of 20 subjects each: one group (mean age 68.4 +/- 5.09 years) was affected by PAD with claudication, while the other group consisted of healthy controls (66.9 +/- 6.1 years). Concentrations of interleukin 6 (IL-6) and tumor necrosis factor alpha (TNFalpha) were determined in plasma, in supernatants and in cells stimulated with 1 mg lipopolysaccharide in all patients. E-selectin (ES), L-selectin (LS) and P-selectin (PS) concentrations and plasma concentrations of VCAM-1 and ICAM-1 were also determined. All determinations were performed in patients at rest and after the treadmill exercise. Resting values of soluble mediators were greater in PAD patients than in controls. They increased in both groups after the treadmill test, even if post-treadmill concentrations were significantly higher in PAD patients (PAD p < 0.001 or 0.0001, controls p < 0.05 or 0.001). These results confirm that white blood cell activation is characteristic of systemic atherosclerosis and that these inflammation markers increase in conditions of hemodynamic stress.
Salvatore Santo Signorelli; Maria Clorinda Mazzarino; Luigi Di Pino; Grazia Malaponte; Carmela Porto; Giuseppe Pennisi; Giuseppe Marchese; Maria Pia Costa; Daniele Digrandi; Gabriella Celotta; Vittorio Virgilio
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Vascular medicine (London, England)     Volume:  8     ISSN:  1358-863X     ISO Abbreviation:  Vasc Med     Publication Date:  2003  
Date Detail:
Created Date:  2003-07-17     Completed Date:  2003-12-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9610930     Medline TA:  Vasc Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  15-9     Citation Subset:  IM    
Department of Internal Medicine and Medical Specialties, Faculty of Medicine, University of Catania, Catania, Italy.
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MeSH Terms
Antineoplastic Agents / blood*
Arterial Occlusive Diseases / blood*,  etiology,  physiopathology*
Arteriosclerosis / blood*,  complications,  physiopathology*
Exercise / physiology*
Exercise Test
Inflammation Mediators / blood
Intercellular Adhesion Molecule-1 / blood*
Interleukin-6 / blood*
Middle Aged
Peripheral Vascular Diseases / blood*,  etiology,  physiopathology*
Rest / physiology*
Selectins / blood*
Tumor Necrosis Factor-alpha / analysis*
Vascular Cell Adhesion Molecule-1 / blood*
Reg. No./Substance:
0/Antineoplastic Agents; 0/Inflammation Mediators; 0/Interleukin-6; 0/Selectins; 0/Tumor Necrosis Factor-alpha; 0/Vascular Cell Adhesion Molecule-1; 126547-89-5/Intercellular Adhesion Molecule-1

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