Document Detail

High chromogranin A cell density in the colon of patients with lymphocytic colitis.
MedLine Citation:
PMID:  21584496     Owner:  NLM     Status:  MEDLINE    
Microscopic colitis (MC) is a chronic condition that is characterized by watery diarrhoea with normal appearance of the colonic mucosa. MC is subdivided into two distinctive entities: lymphocytic colitis (LC) and collagenous colitis (CC). The etiology and pathophysiology of LC remain to be determined. The present study included 9 female patients with LC, with an average age of 34 years. Subjects (n=25) who underwent colonoscopy were used as controls. The subjects underwent colonoscopy due to gastrointestinal bleeding, where the source of bleeding was identified as haemorrhoids, or due to health concerns. The control subjects included 18 females and 7 males, with an average age of 49 years. Colonoscopy was performed in both patient and control groups, and biopsies were obtained from different segments of the colon. The biopsies were immunostained with the avidin-biotin complex method for human leucocytes CD45, collagen type III and chromogranin A (CgA). CgA was quantified by computer image analysis. The density of CgA-immunoreactive cells in patients with LC was significantly higher than that in controls. The high density of colonic CgA, a common marker for endocrine cells, indicates the possibility that colonic hormones are involved in the pathophysiology of LC. Serotonin-containing cells are the major endocrine cell type in the colon and constitute approximately 88% of the total endocrine cell population. It is likely that the increase in colonic CgA in LC patients accounts for an increase in serotonin cells.
M El-Salhy; B Lomholt-Beck; T D Gundersen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2011-05-16
Journal Detail:
Title:  Molecular medicine reports     Volume:  4     ISSN:  1791-3004     ISO Abbreviation:  Mol Med Rep     Publication Date:    2011 Jul-Aug
Date Detail:
Created Date:  2011-06-06     Completed Date:  2011-09-30     Revised Date:  2013-02-22    
Medline Journal Info:
Nlm Unique ID:  101475259     Medline TA:  Mol Med Rep     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  603-5     Citation Subset:  IM    
Department of Medicine, Stord Helse-Fonna Hospital, 54 09 Stord, Norway.
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MeSH Terms
Antigens, CD45 / metabolism
Chromogranin A / metabolism*
Colitis, Lymphocytic / metabolism*,  pathology
Collagen Type III / metabolism
Colon / metabolism*
Image Processing, Computer-Assisted
Middle Aged
Reg. No./Substance:
0/Chromogranin A; 0/Collagen Type III; EC, CD45

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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