Document Detail

High chromium yeast supplementation improves glucose tolerance in pigs by decreasing hepatic extraction of insulin.
MedLine Citation:
PMID:  10801929     Owner:  NLM     Status:  MEDLINE    
Twenty Landrace x Yorkshire cross pigs (body wt, 47.9+/-2.9 kg) were used to evaluate effects of dietary high chromium (Cr) yeast supplementation on plasma kinetics of glucose, insulin and C-peptide. Pigs were provided free access to either a control diet (C) containing 204 microg Cr/kg or a diet supplemented with an additional 200 microg Cr/kg as high Cr yeast (CR) for between 23 and 30 d. After overnight food deprivation, dextrose (500 g/L) was infused through a jugular vein catheter at a dose of 0.5 g glucose/kg body weight with an infusion rate of 10 g glucose/min within 6 min. High Cr yeast supplementation did not affect body weight gain or food intake. There were no differences in fasting plasma concentrations of either glucose or C-peptide, although basal plasma concentration of insulin tended to be higher in pigs fed CR (P<0.10). Plasma glucose concentrations were lower (P<0.01) at postinfusion times 5, 10, 15 and 20 min in pigs fed CR. Plasma insulin concentrations in pigs fed CR were higher (P<0.05) at 2 and 0 min before the completion of dextrose infusion. However, the increase in plasma insulin concentrations was not accompanied by a comparable elevation in plasma C-peptide concentrations. The 30-min (postinfusion) area of plasma glucose concentrations tended to be lower (P<0.10) in pigs fed CR, but there were no differences in 30-min areas of either plasma insulin or plasma C-peptide concentrations between treatments. Plasma clearance rates of glucose, insulin and C-peptide were higher and their half-lives shorter (P<0.05) in pigs fed CR. In conclusion, dietary high Cr yeast supplementation improved glucose tolerance, possibly through a decrease in hepatic extraction of insulin.
X Guan; J J Matte; P K Ku; J L Snow; J L Burton; N L Trottier
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of nutrition     Volume:  130     ISSN:  0022-3166     ISO Abbreviation:  J. Nutr.     Publication Date:  2000 May 
Date Detail:
Created Date:  2000-06-07     Completed Date:  2000-06-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0404243     Medline TA:  J Nutr     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1274-9     Citation Subset:  IM    
Department of Animal Science, Michigan State University, East Lansing, MI 48824, USA.
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MeSH Terms
Blood Glucose / drug effects,  metabolism*
C-Peptide / pharmacokinetics
Chromium / administration & dosage,  pharmacology*
Glucose / administration & dosage,  pharmacokinetics
Glucose Tolerance Test
Infusions, Intravenous
Insulin / blood*,  pharmacokinetics
Liver / drug effects*,  metabolism
Metabolic Clearance Rate
Saccharomyces cerevisiae*
Weight Gain
Reg. No./Substance:
0/Blood Glucose; 0/C-Peptide; 11061-68-0/Insulin; 50-99-7/Glucose; 7440-47-3/Chromium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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