|High cholesterol level is essential for myelin membrane growth.|
|PMID: 15793579 Owner: NLM Status: MEDLINE|
|Cholesterol in the mammalian brain is a risk factor for certain neurodegenerative diseases, raising the question of its normal function. In the mature brain, the highest cholesterol content is found in myelin. We therefore created mice that lack the ability to synthesize cholesterol in myelin-forming oligodendrocytes. Mutant oligodendrocytes survived, but CNS myelination was severely perturbed, and mutant mice showed ataxia and tremor. CNS myelination continued at a reduced rate for many months, and during this period, the cholesterol-deficient oligodendrocytes actively enriched cholesterol and assembled myelin with >70% of the cholesterol content of wild-type myelin. This shows that cholesterol is an indispensable component of myelin membranes and that cholesterol availability in oligodendrocytes is a rate-limiting factor for brain maturation.|
|Gesine Saher; Britta Brügger; Corinna Lappe-Siefke; Wiebke Möbius; Ryu-ichi Tozawa; Michael C Wehr; Felix Wieland; Shun Ishibashi; Klaus-Armin Nave|
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|Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2005-03-27|
|Title: Nature neuroscience Volume: 8 ISSN: 1097-6256 ISO Abbreviation: Nat. Neurosci. Publication Date: 2005 Apr|
|Created Date: 2005-03-29 Completed Date: 2005-06-13 Revised Date: 2006-11-15|
Medline Journal Info:
|Nlm Unique ID: 9809671 Medline TA: Nat Neurosci Country: United States|
|Languages: eng Pagination: 468-75 Citation Subset: IM|
|Department of Neurogenetics, Max Planck Institute of Experimental Medicine, 37075 Goettingen, Germany.|
|APA/MLA Format Download EndNote Download BibTex|
Apolipoproteins E / metabolism
Blotting, Northern / methods
Blotting, Southern / methods
Blotting, Western / methods
Cell Membrane / metabolism
Central Nervous System / metabolism
Cholesterol / deficiency, physiology*
Chromatography, Thin Layer / methods
Creatine / metabolism
Farnesyl-Diphosphate Farnesyltransferase / deficiency, genetics, metabolism
Gene Expression Regulation, Developmental / physiology*
In Situ Hybridization / methods
Mass Spectrometry / methods
Mice, Inbred C57BL
Mice, Mutant Strains / physiology
Microscopy, Electron, Transmission / methods
Microsomes / metabolism
Myelin Proteolipid Protein / metabolism
Myelin Sheath / metabolism*, ultrastructure
Oligodendroglia / metabolism*, ultrastructure
Psychomotor Performance / physiology
RNA / analysis
Receptors, LDL / metabolism
Silver Staining / methods
Spinal Cord / metabolism, ultrastructure
|0/Apolipoproteins E; 0/Myelin Proteolipid Protein; 0/Receptors, LDL; 57-00-1/Creatine; 57-88-5/Cholesterol; 63231-63-0/RNA; EC 220.127.116.11/Farnesyl-Diphosphate Farnesyltransferase; EC 3.1.4.-/2',3'-Cyclic-Nucleotide Phosphodiesterases|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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