| High cholesterol intake modifies chylomicron metabolism in normolipidemic young men. | |
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MedLine Citation:
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PMID: 16549459 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Whether the consumption of egg yolk, which has a very high cholesterol content without excess saturated fats, has deleterious effects on lipid metabolism is controversial. Absorbed dietary cholesterol enters the bloodstream as chylomicrons, but the effects of regular consumption of large amounts of cholesterol on the metabolism of this lipoprotein have not been explored even though the accumulation of chylomicron remnants is associated with coronary artery disease (CAD). We investigated the effects of high dietary cholesterol on chylomicron metabolism in normolipidemic, healthy young men. The plasma kinetics of a chylomicron-like emulsion, doubly-labeled with 14C-cholesteryl ester (14C-CE) and 3H-triolein (3H-TG) were assessed in 25 men (17-22 y old, BMI 24.1 +/- 3.4 kg/m2). One group (n = 13) consumed 174 +/- 41 mg cholesterol/d and no egg yolk. The other group (n = 12) consumed 3 whole eggs/d for a total cholesterol intake of 804 +/- 40 mg/d. The nutritional composition of diets was the same for both groups, including total lipids and saturated fat, which comprised 25 and 7%, respectively, of energy intake. Serum LDL and HDL cholesterol and apoprotein B concentrations were higher in the group consuming the high-cholesterol diet (P < 0.05), but serum triacylglycerol, apo AI, and lipoprotein (a) did not differ between the 2 groups. The fractional clearance rate (FCR) of the 14C-CE emulsion, obtained by compartmental analysis, was 52% slower in the high-cholesterol than in the low-cholesterol group (P < 0.001); the 3H-TG FCR did not differ between the groups. Finally, we concluded that high cholesterol intakes increase the residence time of chylomicron remnants, as indicated by the 14C-CE kinetics, which may have undesirable effects related to the development of CAD. |
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Authors:
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Thais B César; Maria Rita M Oliveira; Carlos H Mesquita; Raul C Maranhão |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The Journal of nutrition Volume: 136 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 2006 Apr |
Date Detail:
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Created Date: 2006-03-21 Completed Date: 2006-05-03 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: United States |
Other Details:
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Languages: eng Pagination: 971-6 Citation Subset: IM |
Affiliation:
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Faculty of Pharmaceutical Sciences, São Paulo State University, Araraquara, São Paulo, Brazil. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Apolipoprotein A-I / blood Apolipoproteins B / blood Carbon Radioisotopes / diagnostic use Cholesterol Esters / blood Cholesterol, Dietary / administration & dosage* Cholesterol, HDL / blood Cholesterol, LDL / blood Chylomicrons / blood* Diet Eggs Emulsions Energy Intake Humans Isotope Labeling Lipids / blood* Lipoprotein(a) / blood Male Triglycerides / blood Triolein / metabolism Tritium / diagnostic use |
| Chemical | |
Reg. No./Substance:
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0/Apolipoprotein A-I; 0/Apolipoproteins B; 0/Carbon Radioisotopes; 0/Cholesterol Esters; 0/Cholesterol, Dietary; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Chylomicrons; 0/Emulsions; 0/Lipids; 0/Lipoprotein(a); 0/Triglycerides; 10028-17-8/Tritium; 122-32-7/Triolein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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