| High carbohydrate diets, triglyceride-rich lipoproteins, and coronary heart disease risk. | |
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MedLine Citation:
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PMID: 11078235 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In this study we compared the effects of variations in dietary fat and carbohydrate (CHO) content on concentrations of triglyceride-rich lipoproteins in 8, healthy, nondiabetic volunteers. The diets contained, as a percentage of total calories, either 60% CHO, 25% fat, and 15% protein, or 40% CHO, 45% fat, and 15% protein. They were consumed in random order for 2 weeks, with a 2-week washout period in between. Measurements were obtained at the end of each dietary period of plasma triglyceride, cholesterol, low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, remnant lipoprotein (RLP) cholesterol, and RLP triglyceride concentrations, both after an overnight fast and throughout an 8-hour period (8 A.M. to 4 P.M.) in response to breakfast and lunch. The 60% CHO diet resulted in higher (mean +/- SEM) fasting plasma triglycerides (206 +/- 50 vs 113 +/- 19 mg/dl, p = 0.03), RLP cholesterol (15 +/- 6 vs 6 +/- 1 mg/dl, p = 0.005), RLP triglyceride (56 +/- 25 vs 16 +/- 3 mg/dl, p = 0.003), and lower HDL cholesterol (39 +/- 3 vs 44 +/- 3 mg/dl, p = 0.003) concentrations, without any change in LDL cholesterol concentration. Furthermore, the changes in plasma triglyceride, RLP cholesterol, and RLP triglyceride persisted throughout the day in response to breakfast and lunch. These results indicate that the effects of lowfat diets on lipoprotein metabolism are not limited to higher fasting plasma triglyceride and lower HDL cholesterol concentrations, but also include a persistent elevation in RLPs. Given the atherogenic potential of these changes in lipoprotein metabolism, it seems appropriate to question the wisdom of recommending that all Americans should replace dietary saturated fat with CHO. |
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Authors:
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F Abbasi; T McLaughlin; C Lamendola; H S Kim; A Tanaka; T Wang; K Nakajima; G M Reaven |
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Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: The American journal of cardiology Volume: 85 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 2000 Jan |
Date Detail:
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Created Date: 2000-11-30 Completed Date: 2000-11-30 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 45-8 Citation Subset: AIM; IM |
Affiliation:
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Stanford University School of Medicine, California, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Apolipoproteins
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blood* Cholesterol / blood* Cholesterol, HDL / blood* Cholesterol, LDL / blood Coronary Disease / etiology* Cross-Over Studies Dietary Carbohydrates / administration & dosage*, adverse effects* Dietary Fats / administration & dosage*, adverse effects* Energy Intake* Fasting Female Humans Lipoproteins / blood* Male Middle Aged Nutrition Policy Time Factors Triglycerides / blood* |
| Grant Support | |
ID/Acronym/Agency:
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HL-08506/HL/NHLBI NIH HHS; RR-00070/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Apolipoproteins; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 0/Dietary Carbohydrates; 0/Dietary Fats; 0/Lipoproteins; 0/Triglycerides; 0/remnant-like particle cholesterol; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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