| High-calcium diet reduces blood pressure, blood volume and preserves vasorelaxation in oral contraceptive-treated female rats. | |
| | |
MedLine Citation:
|
PMID: 20036339 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Cardiovascular complications are the major clinical challenges among users of synthetic steroids in oral contraceptive (OC) formulations. Interventions that reduce blood volume and improve vasorelaxation have been shown to reduce hypertension and the associated risk factors. The aim of the present study was to investigate the influence of increasing dietary calcium from 0.9 to 3.0% on the development of OC-induced high blood pressure and associated changes in female Sprague-Dawley rats treated with a combination of OC steroids (1 microg ethinyl estradiol and 10 microg norgestrel; p.o.) daily for 10 weeks. Results showed that OC administration led to significant increases in blood pressure, blood volume and cardiac weight. Conversely, OC caused significant reductions in body weight, urinary excretion of water, plasma levels of calcium, 17beta-estradiol and progesterone. Increased dietary calcium attenuated the elevation in blood pressure induced by OC and abrogated the associated changes in blood volume, cardiac weight, plasma calcium and urinary excretion of water. The endothelium-dependent relaxation responses to acetylcholine and endothelium-independent relaxation responses to sodium nitroprusside in noradrenaline-precontracted aortic rings were not significantly different among the groups. The results indicate that increased calcium intake abrogated the development of high blood pressure and associated increased blood volume and cardiac weight during OC treatment. The beneficial effect of increased dietary calcium during OC use may be explained by improved diuretic and preserved vasorelaxant responses. |
| | |
Authors:
|
Lawrence A Olatunji; Ayodele O Soladoye |
Related Documents
:
|
2805439 - The effects of sodium loading on cardiopulmonary baroreflexes. 6654449 - Hemodynamic mechanisms of adaptation to chronic high sodium intake in normal humans. 10678539 - Controlled study of circadian rhythm of blood pressure in patients with aldosterone-pro... 6783199 - Evidence for a circulating sodium transport inhibitor in essential hypertension. 1706039 - The effect of sodium intake on ventricular performance in healthy men. 3899419 - Effect of hydralazine on serial measurements of exchangeable sodium and blood pressure ... 22110879 - Comparison of the central venous pressure from internal jugular vein and the pressure m... 15913519 - The effects of a medializing calcaneal osteotomy with and without superior translation ... 16129819 - N-terminal pro brain natriuretic peptide is inversely related to metabolic cardiovascul... |
Publication Detail:
|
Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't Date: 2009-12-24 |
Journal Detail:
|
Title: Vascular pharmacology Volume: 52 ISSN: 1879-3649 ISO Abbreviation: Vascul. Pharmacol. Publication Date: 2010 Jan-Feb |
Date Detail:
|
Created Date: 2010-02-17 Completed Date: 2010-09-29 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 101130615 Medline TA: Vascul Pharmacol Country: United States |
Other Details:
|
Languages: eng Pagination: 95-100 Citation Subset: IM |
Copyright Information:
|
2009 Elsevier Inc. All rights reserved. |
Affiliation:
|
Department of Physiology, College of Health Sciences, University of Ilorin, P.M.B. 1515 Ilorin 240001, Nigeria. tunjilaw@unilorin.edu.ng |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Blood Pressure / drug effects*, physiology Blood Volume / drug effects*, physiology Calcium / administration & dosage, blood Calcium, Dietary / administration & dosage* Contraceptives, Oral / adverse effects*, blood Female Hypertension / chemically induced, drug therapy, physiopathology Rats Rats, Sprague-Dawley Treatment Outcome Vasodilation / drug effects*, physiology |
| Chemical | |
Reg. No./Substance:
|
0/Calcium, Dietary; 0/Contraceptives, Oral; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Uncinate processes in birds: morphology, physiology and function.
Next Document: Tetrandrine attenuates lipopolysaccharide-induced fulminant hepatic failure in D-galactosamine-sensi...