Document Detail


High bone turnover of type I collagen depends on fetal growth.
MedLine Citation:
PMID:  16214433     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The bone metabolic processes of proliferation and differentiation in preterm and term newborns have yet to be fully elucidated. Seventy-four umbilical cord blood samples were collected from preterm and term newborns delivered at 27 to 42 gestational weeks (GWs). Carboxy-terminal propeptide of type I procollagen (PICP), pyridinoline cross-linked telopeptide domain of type I collagen (ICTP), alkaline phosphatase (ALP), and bone-specific alkaline phosphatase (BAP) were measured. Calcitonin (CT), estrogen (E2), intact parathyroid hormone, and insulin-like growth factor-I (IGF-I) were also examined in 20 or 23 randomly selected samples. We conducted cross-sectional regression analyses for bone metabolic markers, fetal growth markers including GWs, birth weight (BW), height (BH) and head circumference (HC), and bone related hormones. PICP and ICTP activities were very high, but decreased significantly with fetal growth based on GWs, BW, BH, and HC changes (GWs, BW, and BH to both PICP and ICTP, P < 0.0001; HC to ICTP, P < 0.0001; HC to PICP, P < 0.05), while BAP and ALP did not change significantly. E2 and CT both showed a significant positive correlation with Ca (P < 0.05), but neither hormone had any apparent correlation with PICP, ALP, BAP, or ICTP. These results suggest very active bone formation and resorption of type I collagen to be dependent on fetal growth and that fetal osteoblasts dominate the proliferation phase of development rather than the maturation phase. However, factors contributing to high bone turnover in the fetus remain to be elucidated.
Authors:
Kazutoshi Nakano; Toshiyuki Iwamatsu; Cong Mei Wang; Mikako Tarasima; Tomohiro Nakayama; Kaori Sasaki; Emiko Tachikawa; Naoko Noda; Eriko Mizoguchi; Makiko Osawa
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Publication Detail:
Type:  Journal Article     Date:  2005-10-07
Journal Detail:
Title:  Bone     Volume:  38     ISSN:  8756-3282     ISO Abbreviation:  Bone     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-02-06     Completed Date:  2006-08-10     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8504048     Medline TA:  Bone     Country:  United States    
Other Details:
Languages:  eng     Pagination:  249-56     Citation Subset:  IM    
Affiliation:
Department of Pediatrics, Tokyo Women's Medical University, 8-1, Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan. knakano@ped.twmu.ac.jp
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MeSH Terms
Descriptor/Qualifier:
Biological Markers / analysis*
Body Height
Bone and Bones / metabolism*
Collagen Type I / metabolism*
Cross-Sectional Studies
Fetal Development / physiology*
Hormones / metabolism,  physiology*
Humans
Infant, Newborn
Osteogenesis
Regression Analysis
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Collagen Type I; 0/Hormones

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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