Document Detail


High blood pressure and visual sensitivity.
MedLine Citation:
PMID:  12968642     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The study had two main purposes: (1) to determine whether the foveal visual sensitivities of people treated for high blood pressure (vascular hypertension) differ from the sensitivities of people who have not been diagnosed with high blood pressure and (2) to understand how visual adaptation is related to standard measures of systemic cardiovascular function. Two groups of middle-aged subjects--hypertensive and normotensive--were examined with a series of test/background stimulus combinations. All subjects met rigorous inclusion criteria for excellent ocular health. Although the visual sensitivities of the two subject groups overlapped extensively, the age-related rate of sensitivity loss was, for some measures, greater for the hypertensive subjects, possibly because of adaptation differences between the two groups. Overall, the degree of steady-state sensitivity loss resulting from an increase of background illuminance (for 580-nm backgrounds) was slightly less for the hypertensive subjects. Among normotensive subjects, the ability of a bright (3.8-log-td), long-wavelength (640-nm) adapting background to selectively suppress the flicker response of long-wavelength-sensitive (LWS) cones was related inversely to the ratio of mean arterial blood pressure to heart rate. The degree of selective suppression was also related to heart rate alone, and there was evidence that short-term changes of cardiovascular response were important. The results suggest that (1) vascular hypertension, or possibly its treatment, subtly affects visual function even in the absence of eye disease and (2) changes in blood flow affect retinal light-adaptation processes involved in the selective suppression of the flicker response from LWS cones caused by bright, long-wavelength backgrounds.
Authors:
Alvin Eisner; John R Samples
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of the Optical Society of America. A, Optics, image science, and vision     Volume:  20     ISSN:  1084-7529     ISO Abbreviation:  J Opt Soc Am A Opt Image Sci Vis     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-12     Completed Date:  2003-11-07     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  9800943     Medline TA:  J Opt Soc Am A Opt Image Sci Vis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1681-93     Citation Subset:  IM    
Affiliation:
Neurological Sciences Institute, Oregon Health & Science University, West Campus, 505 N.W. 185 Avenue, Beaverton, Oregon 97006, USA. eisnera@ohsu.edu
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MeSH Terms
Descriptor/Qualifier:
Adaptation, Physiological
Adult
Aged
Automation
Female
Heart Rate
Humans
Hypertension / physiopathology*
Male
Middle Aged
Perimetry
Vision, Ocular*
Grant Support
ID/Acronym/Agency:
EY12737/EY/NEI NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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