Document Detail


High blood pressure and obesity increase the risk of abnormal glucose tolerance in young adult african americans.
MedLine Citation:
PMID:  21649838     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Higher prevalence of both hypertension and obesity in African Americans is associated with a disproportionately greater burden of cardiovascular diseases in this ethnic group. The purpose of this study was to examine whether there is an interaction between hypertension and obesity that significantly increases the expression of metabolic risk factors for cardiovascular disease. Four groups of young adult African Americans were recruited based on their weight and blood pressure (BP). The effects of weight and BP on metabolic risk factors were analyzed based on data obtained from 484 patients. Results demonstrated that high BP and obesity were independently associated with increased odds of abnormal glucose tolerance, 1.8- and 2.2-fold, respectively. The coexistence of both high BP and obesity further increased the odds of abnormal glucose tolerance 4-fold. In addition, the geometric mean of homeostasis model assessment, an estimate of insulin resistance, increased by 18% with high BP, 60% with obesity, and 90% with the presence of both high BP and obesity. Although no statistically significant interaction between high BP and obesity was detected, the relationships of both high BP and obesity with metabolic risk factors were clearly additive.J Clin Hypertens (Greenwich). 2011;13:397-403. ©2011 Wiley Periodicals, Inc.
Authors:
Yonghong Huan; Stephanie Deloach; Scott W Keith; Edward C Pequignot; Bonita Falkner
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Publication Detail:
Type:  Journal Article     Date:  2011-01-31
Journal Detail:
Title:  Journal of clinical hypertension (Greenwich, Conn.)     Volume:  13     ISSN:  1751-7176     ISO Abbreviation:  J Clin Hypertens (Greenwich)     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-06-08     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100888554     Medline TA:  J Clin Hypertens (Greenwich)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  397-403     Citation Subset:  IM    
Copyright Information:
© 2011 Wiley Periodicals, Inc.
Affiliation:
From the Division of Nephrology, Department of Medicine, Thomas Jefferson University, Philadelphia, PA;the Division of Biostatistics, Department of Pharmacology and Experimental Therapeutics, Thomas Jefferson University, Philadelphia, PA.
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