Document Detail

High blood pressure in women.
MedLine Citation:
PMID:  9222804     Owner:  NLM     Status:  MEDLINE    
There is a sexual dimorphism in blood pressure of humans and experimental animals: males tend to have higher blood pressure than females with functional ovaries, while ovariectomy or menopause tends to abolish the sexual dimorphism and cause females to develop a "male" pattern of blood pressure. Hypertensive male laboratory animals tend to have NaCl-sensitive blood pressure, while females are NaCl resistant unless their ovaries are removed, in which case NaCl sensitivity appears. The hormonal basis of NaCl sensitivity of blood pressure and of the sexual dimorphism of hypertension remains to be defined. Synthetic estrogens and progestins, as found in oral contraceptives, tend to elevate blood pressure, while naturally occurring estrogens lower it, or have no effect. Hypertension increases cardiovascular risk in women, as well as men, although the benefits of antihypertensive treatment have been more difficult to demonstrate in women. In the population of the United States, women are more aware of their hypertension, more likely to be treated medically, and more likely to have their blood pressure controlled.
D A Calhoun; S Oparil
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of fertility and women's medicine     Volume:  42     ISSN:  1534-892X     ISO Abbreviation:  Int J Fertil Womens Med     Publication Date:    1997 May-Jun
Date Detail:
Created Date:  1997-08-29     Completed Date:  1997-08-29     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9706778     Medline TA:  Int J Fertil Womens Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  198-205     Citation Subset:  IM    
Vascular Biology and Hypertension Program, University of Alabama at Birmingham, Birmingham, Alabama, USA.
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MeSH Terms
Antihypertensive Agents / contraindications,  therapeutic use*
Contraceptives, Oral / adverse effects*
Disease Models, Animal
Estrogen Replacement Therapy
Hypertension* / drug therapy,  etiology,  physiopathology
Middle Aged
Pregnancy Complications / physiopathology
Risk Factors
Sex Factors
Women's Health*
Reg. No./Substance:
0/Antihypertensive Agents; 0/Contraceptives, Oral

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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