| High blood glucose does not adversely affect outcome in moderately brain-injured rodents. | |
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MedLine Citation:
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PMID: 20504157 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In a number of clinical studies researchers have reported that acute hyperglycemia is associated with increased mortality and worsened neurological outcome in patients with traumatic brain injury (TBI). In contrast, it has been demonstrated that intensive insulin therapy to lower blood glucose can lead to an increased frequency of hypoglycemic episodes and poor outcome. Consistent with this, experimental and clinical studies have shown that TBI causes a "metabolic crisis" in the injured brain, suggesting that a reduction in glucose availability may exacerbate brain damage. We therefore examined the consequences of hyperglycemia on cognitive and pathological measures. Using a rodent model of TBI, we find that when acute hyperglycemia is induced in animals prior to injury, there is little to no change in motor and cognitive performance, contusion volume, or cerebral edema. To examine the consequences of persistent hyperglycemia (as seen in diabetic patients), animals were treated with streptozotocin (STZ) to induce type 1 diabetes. We find that the presence of persistent STZ-induced hyperglycemia results in a reduction of brain edema. Insulin therapy to reduce blood glucose reverses this beneficial effect of hyperglycemia. Taken together, our results indicate that an acute increase in blood glucose levels may not be harmful, and that intervention with insulin therapy to lower blood glucose levels in TBI patients may increase secondary brain damage. |
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Authors:
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Julia Hill; Jing Zhao; Pramod K Dash |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Journal of neurotrauma Volume: 27 ISSN: 1557-9042 ISO Abbreviation: J. Neurotrauma Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-08-17 Completed Date: 2010-12-02 Revised Date: 2011-08-03 |
Medline Journal Info:
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Nlm Unique ID: 8811626 Medline TA: J Neurotrauma Country: United States |
Other Details:
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Languages: eng Pagination: 1439-48 Citation Subset: IM |
Affiliation:
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Department of Neurobiology and Anatomy, The University of Texas Medical School, Houston, Texas 77225, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Blood Glucose / physiology* Brain Edema / etiology, pathology Brain Injuries / blood, pathology*, psychology* Diabetes Mellitus, Experimental / complications Glucose / pharmacology Hyperglycemia / complications Hypoglycemic Agents / pharmacology Insulin / pharmacology Male Maze Learning / physiology Mice Mice, Inbred C57BL Motor Skills / physiology Psychomotor Performance / physiology Rats Rats, Sprague-Dawley Reflex, Vestibulo-Ocular / physiology |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Hypoglycemic Agents; 11061-68-0/Insulin; 50-99-7/Glucose |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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