Document Detail

High association of anticardiolipin antibodies with psychosis.
MedLine Citation:
PMID:  9491061     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Lupus anticoagulant (LA) and anticardiolipin antibodies (aCL) are autoantibodies that can be detected in plasma or serum of patients with autoimmune-related diseases. The presence of these autoantibodies has been associated with recurrent arterial and/or venous thromboembolism as well as with recurrent fetal loss and thrombocytopenia. In recent years, other medical conditions such as dementia, chorea, psychosis, migraine, and peripheral neuropathy have been associated with these autoantibodies. An adverse response to neuroleptic treatment was reported to be associated with the presence of autoantibodies, but these patients rarely developed clinical vascular manifestations. METHOD: We conducted a study of 34 unmedicated patients admitted to the hospital with acute psychosis in whom aCL and LA were examined before and after neuroleptic treatment to determine the presence of antibodies relative to the treatment condition. RESULTS: 32% (11/34) of the unmedicated psychotic patients had antiphospholipid antibodies: we detected elevated titers of IgG-aCL isotype in 24% (8/34) of unmedicated patients (p < .02 compared with 20 normal controls, none of whom tested positive), and 9% (3/34) had LA. Twenty-two patients were followed up after medication; 31.8% (7/22) of these patients showed moderate titers of IgG-aCL (p < .28), and 18.2% (4/22) were LA positive. Altogether, antiphospholipid antibodies were detected in 40.9% (9/22) of the medicated patients. CONCLUSION: This study shows the increased incidence of LA and aCL antibodies in neuroleptic-treated psychotic patients and the possible association between psychosis and antiphospholipid antibodies.
M Schwartz; M Rochas; B Weller; A Sheinkman; I Tal; D Golan; N Toubi; I Eldar; B Sharf; D Attias
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of clinical psychiatry     Volume:  59     ISSN:  0160-6689     ISO Abbreviation:  J Clin Psychiatry     Publication Date:  1998 Jan 
Date Detail:
Created Date:  1998-03-10     Completed Date:  1998-03-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7801243     Medline TA:  J Clin Psychiatry     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  20-3     Citation Subset:  IM    
Department of Neurology, Bnai Zion Medical Center, Haifa, Israel.
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MeSH Terms
Acute Disease
Antibodies, Anticardiolipin / blood*
Antipsychotic Agents / therapeutic use
Fluorescent Antibody Technique, Indirect
Follow-Up Studies
Immunoglobulin G / blood
Lupus Coagulation Inhibitor / blood
Middle Aged
Psychotic Disorders / blood,  drug therapy,  immunology*
Reg. No./Substance:
0/Antibodies, Anticardiolipin; 0/Antipsychotic Agents; 0/Immunoglobulin G; 0/Lupus Coagulation Inhibitor

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