Document Detail


High amplitude propagated contractions.
MedLine Citation:
PMID:  23057554     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
While most colonic motor activity is segmental and non-propulsive, colonic high amplitude propagated contractions (HAPC) can transfer colonic contents over long distances and often precede defecation. High amplitude propagated contractions occur spontaneously, in response to pharmacological agents or colonic distention. A subset of patients with slow transit constipation have fewer HAPC. In this issue of Neurogastroenterology and Motility, Rodriguez et al. report that anal relaxation during spontaneous and bisacodyl-induced HAPC exceeds anal relaxation during rectal distention in constipated children undergoing colonic manometry. Moreover, and consistent with a neural mechanism, anal relaxation often precedes arrival of HAPC in the left colon. High amplitude propagated contractions are also used to evaluate the motor response to a meal and pharmacological stimuli (e.g., bisacodyl, neostigmine) and to identify colonic inertia during colonic motility testing in chronic constipation. This editorial comprehensively reviews the characteristics, physiology and pharmacology of HAPC, their assessment by manometry, and relevance to constipation and diarrhea.
Authors:
A E Bharucha
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Publication Detail:
Type:  Editorial; Research Support, N.I.H., Extramural; Review    
Journal Detail:
Title:  Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society     Volume:  24     ISSN:  1365-2982     ISO Abbreviation:  Neurogastroenterol. Motil.     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-10-12     Completed Date:  2013-06-14     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9432572     Medline TA:  Neurogastroenterol Motil     Country:  England    
Other Details:
Languages:  eng     Pagination:  977-82     Citation Subset:  IM    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
Division of Gastroenterology and Hepatology, College of Medicine, Mayo Clinic, Rochester, MN 55905, USA. bharucha.adil@mayo.edu
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MeSH Terms
Descriptor/Qualifier:
Constipation / physiopathology*
Gastrointestinal Motility / physiology*
Humans
Muscle Contraction / physiology*
Muscle, Smooth / physiopathology*
Grant Support
ID/Acronym/Agency:
P01 DK 68055/DK/NIDDK NIH HHS; P01 DK068055/DK/NIDDK NIH HHS; R01 DK078924/DK/NIDDK NIH HHS; R01 DKDK78924//PHS HHS
Comments/Corrections

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