Document Detail

High-amplitude QRS complex in the electrocardiograms of normotensive people and risk of subsequent hypertension.
MedLine Citation:
PMID:  12957727     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Left ventricular hypertrophy sometimes develops in normotensive people with a genetic background for hypertension. The aim of this case-control study was to test the hypothesis that a high-amplitude QRS complex (high-QRS) is indicative of risk of eventual hypertension. METHODS: We reviewed medical charts that included blood pressure data obtained every 6 months from 7011 Japanese workers. The cases were all of 24 normotensive people showing an electrocardiogram with SV1+RV5>4.0 mV (high-QRS). The 24 controls chosen presented normal electrocardiograms and were matched for blood pressure, body mass index, age, gender, glycated hemoglobin A1c fraction, and parental occurrence of hypertension. The incidence of hypertension and change in blood pressure during a 5-year study period were compared in the two groups. RESULTS: The cases were more likely than the controls to have a parent with hypertension (18/24 [75.0%] and 686/5704 [12.0%], respectively; P<0.01, odds ratio=21.8 [95% CI: 8.6-55.2]). At the end of the study period, hypertension was more frequent (18/24 [75.0%] and 3/24 [12.5%], respectively; P<0.01, odds ratio=21.0 [95% CI; 4.6-96.2]) and both systolic and diastolic blood pressures were higher (149.0+/-17.1 mmHg vs. 139+/-17.1 mmHg, P<0.01; and 89.5+/-9.2 mmHg vs. 81.7+/-11.5 mmHg, P=0.01, respectively) in the cases than in the controls. CONCLUSIONS: High-QRS may be indicative of risk of eventual hypertension, and may therefore be useful for screening purposes.
Yutaka Takeda; Tatsuya Fukutomi; Shogo Suzuki; Gen'i Murasaki; Hiroaki Okutani; Itoh Makoto
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of cardiology     Volume:  91     ISSN:  0167-5273     ISO Abbreviation:  Int. J. Cardiol.     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-09-05     Completed Date:  2004-02-26     Revised Date:  2006-07-12    
Medline Journal Info:
Nlm Unique ID:  8200291     Medline TA:  Int J Cardiol     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  37-42     Citation Subset:  IM    
Department of Internal Medicine and Bioregulation, Nagoya City University Graduate School of Medical Sciences, Nagoya, Japan.
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MeSH Terms
Cardiomegaly / diagnosis,  genetics
Case-Control Studies
Hypertension / diagnosis*,  genetics,  prevention & control*
Middle Aged
Risk Factors

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