| High altitude simulation, substance P and airway rapidly adapting receptor activity in rabbits. | |
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MedLine Citation:
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PMID: 21787887 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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To investigate whether there is a change in airway rapidly adapting receptor (RAR) activity during high altitude exposure, rabbits were placed in a high altitude simulation chamber (barometric pressure, 429mm Hg). With 12h exposure, when there was pulmonary congestion, an increase in basal RAR activity was observed. With 36h exposure, when there was alveolar edema, there was a further increase in basal RAR activity. In these backgrounds, there was an increase in the sensitivity of the RARs to substance P (SP). To assess whether there was an increase in lung SP level, neutral endopeptidase activity was determined which showed a decrease in low barometric pressure exposed groups. It is concluded that along with the SP released, pulmonary congestion and edema produced, respectively by different durations of low barometric pressure exposure cause a progressive increase in RAR activity which may accounts for the respiratory symptoms reported in climbers who are unacclimatized. |
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Authors:
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R Bhagat; A Yasir; A Vashisht; R Kulshreshtha; S B Singh; K Ravi |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-7-20 |
Journal Detail:
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Title: Respiratory physiology & neurobiology Volume: - ISSN: 1878-1519 ISO Abbreviation: - Publication Date: 2011 Jul |
Date Detail:
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Created Date: 2011-7-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101140022 Medline TA: Respir Physiol Neurobiol Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Copyright Information:
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Copyright © 2011. Published by Elsevier B.V. |
Affiliation:
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Department of Physiology, V. P. Chest Institute, Univ. of Delhi, Delhi, India. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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